POU6F2 - POU class 6 homeobox 2 Gene

Also Known as WT5; WTSL; RPF-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11281

About POU6F2

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:38,977,909-39,468,601 (from NCBI)

This gene has 12 transcripts (splice variants), 218 orthologues, 17 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

POU6F2 Products (3)

mRNA	Protein	Name
NM_001166018.2	NP_001159490.1	POU domain, class 6, transcription factor 2 isoform 2
NM_001370959.1	NP_001357888.1	POU domain, class 6, transcription factor 2 isoform 3
NM_007252.4	NP_009183.3	POU domain, class 6, transcription factor 2 isoform 1

POU6F2 Protein Structure

Pou

Homeobox

0
200
400
600
691 a.a.

Protein Preferred Names	Protein Names
POU domain, class 6, transcription factor 2	Wilms tumor suppressor locus

POU6F2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	POU6F2	P78424	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	POU6F2	P78424	CHAF1A	Homo sapiens	Q13111	Validated Y2H	32296183
Intra	POU6F2	P78424	IQUB	Homo sapiens	Q8NA54	Validated Y2H	32296183
Intra	POU6F2	P78424	MYL7	Homo sapiens	Q01449	Validated Y2H	32296183
Intra	POU6F2	P78424	BFSP2	Homo sapiens	Q13515	Validated Y2H	32296183
Intra	POU6F2	P78424	PDE6H	Homo sapiens	Q13956	Validated Y2H	32296183
Intra	POU6F2	P78424	ZFHX3	Homo sapiens	Q15911-2	Validated Y2H	32296183
Intra	POU6F2	P78424	FNDC3B	Homo sapiens	Q53EP0-3	Validated Y2H	32296183
Intra	POU6F2	P78424	TRIM74	Homo sapiens	Q86UV6-2	Validated Y2H	32296183
Intra	POU6F2	P78424	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	POU6F2	P78424	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	KRTAP8-1	Homo sapiens	Q8IUC2	Validated Y2H	32296183
Intra	POU6F2	P78424	CIB3	Homo sapiens	Q96Q77	Validated Y2H	32296183
Intra	POU6F2	P78424	NEUROG3	Homo sapiens	Q9Y4Z2	Validated Y2H	32296183
Intra	POU6F2	P78424	PADI4	Homo sapiens	Q9UM07	Validated Y2H	32296183
Intra	POU6F2	P78424	RELA	Homo sapiens	Q96CP1	Validated Y2H	32296183
Intra	POU6F2	P78424	MSRB3	Homo sapiens	Q8IXL7-2	Validated Y2H	32296183
Intra	POU6F2	P78424	TRIML2	Homo sapiens	Q8N7C3	Validated Y2H	32296183
Intra	POU6F2	P78424	PM20D2	Homo sapiens	Q8IYS1	Validated Y2H	32296183
Intra	POU6F2	P78424	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	POU6F2	P78424	POU2F1	Homo sapiens	P14859-6	Y2H Array	32296183
Intra	POU6F2	P78424	POU2F1	Homo sapiens	P14859-6	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	SORL1	Homo sapiens	Q92673	Validated Y2H	32296183
Intra	POU6F2	P78424	ZNF410	Homo sapiens	Q86VK4-3	Validated Y2H	32296183
Intra	POU6F2	P78424	ZNF148	Homo sapiens	Q9UQR1-2	Validated Y2H	32296183
Intra	POU6F2	P78424	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
Intra	POU6F2	P78424	HOXC5	Homo sapiens	Q00444	Validated Y2H	32296183
Intra	POU6F2	P78424	IGFN1	Homo sapiens	Q86VF2-5	Validated Y2H	32296183
Intra	POU6F2	P78424	NFYC	Homo sapiens	Q13952-2	Validated Y2H	32296183
Intra	POU6F2	P78424	ZIM2	Homo sapiens	Q9NZV7	Validated Y2H	32296183
Intra	POU6F2	P78424	CTNNA3	Homo sapiens	Q9UI47-2	Validated Y2H	32296183
Intra	POU6F2	P78424	VEZF1	Homo sapiens	Q14119	Validated Y2H	32296183
Intra	POU6F2	P78424	ZNF319	Homo sapiens	Q9P2F9	Validated Y2H	32296183
Intra	POU6F2	P78424	KDF1	Homo sapiens	Q8NAX2	Validated Y2H	32296183
Intra	POU6F2	P78424	ASB13	Homo sapiens	Q8WXK3-2	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	ASB13	Homo sapiens	Q8WXK3-2	Validated Y2H	32296183
Intra	POU6F2	P78424	ASB13	Homo sapiens	Q8WXK3-2	Y2H Array	32296183
Intra	POU6F2	P78424	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	POU6F2	P78424	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	POU6F2	P78424	STRA8	Homo sapiens	Q7Z7C7	Validated Y2H	32296183
Intra	POU6F2	P78424	OAZ3	Homo sapiens	Q9UMX2-2	Validated Y2H	32296183
Intra	POU6F2	P78424	UFSP1	Homo sapiens	Q6NVU6	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	UFSP1	Homo sapiens	Q6NVU6	Validated Y2H	32296183
Intra	POU6F2	P78424	UFSP1	Homo sapiens	Q6NVU6	Y2H Array	32296183
Intra	POU6F2	P78424	LARP4	Homo sapiens	Q6P4E2	Validated Y2H	32296183
Intra	POU6F2	P78424	VAX2	Homo sapiens	Q9UIW0	Validated Y2H	32296183
Intra	POU6F2	P78424	ANKRD10	Homo sapiens	Q9NXR5-2	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	ANKRD10	Homo sapiens	Q9NXR5-2	Validated Y2H	32296183
Intra	POU6F2	P78424	ANKRD10	Homo sapiens	Q9NXR5-2	Y2H Array	32296183
Intra	POU6F2	P78424	SSUH2	Homo sapiens	Q9Y2M2-2	Validated Y2H	32296183
Intra	POU6F2	P78424	THADA	Homo sapiens	Q6YHU6-6	Validated Y2H	32296183
Intra	POU6F2	P78424	PLAAT1	Homo sapiens	Q9HDD0	Validated Y2H	32296183
Intra	POU6F2	P78424	PLAAT1	Homo sapiens	Q9HDD0	Y2H Array	32296183
Intra	POU6F2	P78424	PLAAT1	Homo sapiens	Q9HDD0	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	PRR20D	Homo sapiens	P86480	Validated Y2H	32296183
Intra	POU6F2	P78424	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	PRR20D	Homo sapiens	P86480	Y2H Array	32296183
Intra	POU6F2	P78424	TSC1	Homo sapiens	Q86WV8	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	TSC1	Homo sapiens	Q86WV8	Validated Y2H	32296183
Intra	POU6F2	P78424	TSC1	Homo sapiens	Q86WV8	Y2H Array	32296183
Intra	POU6F2	P78424	MLLT10	Homo sapiens	P55197-2	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	MLLT10	Homo sapiens	P55197-2	Y2H Array	32296183
Intra	POU6F2	P78424	PPIP5K2	Homo sapiens	O43314-2	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	PPIP5K2	Homo sapiens	O43314-2	Y2H Array	32296183
Intra	POU6F2	P78424	PIBF1	Homo sapiens	Q4G0R1	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	PIBF1	Homo sapiens	Q4G0R1	Validated Y2H	32296183
Intra	POU6F2	P78424	ARHGEF6	Homo sapiens	Q15052	Validated Y2H	32296183
Intra	POU6F2	P78424	ZNF574	Homo sapiens	Q6ZN55-2	Validated Y2H	32296183
Intra	POU6F2	P78424	LONRF1	Homo sapiens	Q17RB8	Validated Y2H	32296183
Intra	POU6F2	P78424	ZFP1	Homo sapiens	Q6P2D0	Validated Y2H	32296183
Intra	POU6F2	P78424	PPIL1	Homo sapiens	Q9Y3C6	Validated Y2H	32296183
Intra	POU6F2	P78424	ZBTB4	Homo sapiens	Q9P1Z0	Validated Y2H	32296183
Intra	POU6F2	P78424	STAC	Homo sapiens	Q99469	Validated Y2H	32296183
Intra	POU6F2	P78424	KLHL11	Homo sapiens	Q9NVR0	Validated Y2H	32296183
Intra	POU6F2	P78424	QRICH1	Homo sapiens	Q2TAL8	Validated Y2H	32296183
Intra	POU6F2	P78424	FOSB	Homo sapiens	P53539	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	FOSB	Homo sapiens	P53539	Y2H Array	32296183
Intra	POU6F2	P78424	LMNB2	Homo sapiens	Q03252	Validated Y2H	32296183
Intra	POU6F2	P78424	ACTN3	Homo sapiens	Q08043	Validated Y2H	32296183
Intra	POU6F2	P78424	CDC37	Homo sapiens	Q16543	Validated Y2H	32296183
Intra	POU6F2	P78424	KPNA6	Homo sapiens	O60684	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	KPNA6	Homo sapiens	O60684	Y2H Array	32296183
Intra	POU6F2	P78424	TSEN15	Homo sapiens	Q8WW01	Validated Y2H	32296183
Intra	POU6F2	P78424	PARVG	Homo sapiens	Q9HBI0	Validated Y2H	32296183
Intra	POU6F2	P78424	RBM39	Homo sapiens	Q14498	Validated Y2H	32296183
Intra	POU6F2	P78424	CDC23	Homo sapiens	Q9UJX2	Validated Y2H	32296183
Intra	POU6F2	P78424	TP53BP1	Homo sapiens	Q12888	Y2H Array	32296183
Intra	POU6F2	P78424	TP53BP1	Homo sapiens	Q12888	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	TP53BP1	Homo sapiens	Q12888	Validated Y2H	32296183
Intra	POU6F2	P78424	MORF4L2	Homo sapiens	Q15014	Validated Y2H	32296183
Intra	POU6F2	P78424	KPNA5	Homo sapiens	O15131	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	KPNA5	Homo sapiens	O15131	Y2H Array	32296183
Intra	POU6F2	P78424	POLR3C	Homo sapiens	Q9BUI4	Validated Y2H	32296183
Intra	POU6F2	P78424	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	POU6F2	P78424	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	PKN1	Homo sapiens	Q16512	Validated Y2H	32296183
Intra	POU6F2	P78424	MIEN1	Homo sapiens	Q9BRT3	Validated Y2H	32296183
Intra	POU6F2	P78424	SMAD5	Homo sapiens	Q99717	Validated Y2H	32296183
Intra	POU6F2	P78424	ISX	Homo sapiens	Q2M1V0	Validated Y2H	32296183
Intra	POU6F2	P78424	MSX2	Homo sapiens	P35548	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	MSX2	Homo sapiens	P35548	Y2H Array	32296183
Intra	POU6F2	P78424	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	FHL2	Homo sapiens	Q14192	Validated Y2H	32296183
Intra	POU6F2	P78424	FHL2	Homo sapiens	Q14192	Y2H Array	32296183
Intra	POU6F2	P78424	TCEA2	Homo sapiens	Q15560	Validated Y2H	32296183
Intra	POU6F2	P78424	CDKN2C	Homo sapiens	P42773	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	EIF3F	Homo sapiens	O00303	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	EIF3F	Homo sapiens	O00303	Y2H Array	32296183
Intra	POU6F2	P78424	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	POU6F2	P78424	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	GLIS2	Homo sapiens	Q9BZE0	Validated Y2H	32296183
Intra	POU6F2	P78424	CINP	Homo sapiens	Q9BW66	Validated Y2H	32296183
Intra	POU6F2	P78424	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	POU6F2	P78424	L3MBTL2	Homo sapiens	Q969R5	Validated Y2H	32296183
Intra	POU6F2	P78424	RBPMS	Homo sapiens	Q93062-3	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	RBPMS	Homo sapiens	Q93062-3	Validated Y2H	32296183
Intra	POU6F2	P78424	RBPMS	Homo sapiens	Q93062-3	Y2H Array	32296183
Intra	POU6F2	P78424	DYDC1	Homo sapiens	Q8WWB3	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	DYDC1	Homo sapiens	Q8WWB3	Validated Y2H	32296183
Intra	POU6F2	P78424	DYDC1	Homo sapiens	Q8WWB3	Y2H Array	32296183
Intra	POU6F2	P78424	EIF4EBP1	Homo sapiens	Q13541	Validated Y2H	32296183
Intra	POU6F2	P78424	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
Intra	POU6F2	P78424	SIX1	Homo sapiens	Q15475	Validated Y2H	32296183
Intra	POU6F2	P78424	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	POU6F2	P78424	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32296183
Intra	POU6F2	P78424	UBAC1	Homo sapiens	Q9BSL1	Validated Y2H	32296183
Intra	POU6F2	P78424	MAGEA12	Homo sapiens	P43365	Y2H Array	32296183
Intra	POU6F2	P78424	MAGEA12	Homo sapiens	P43365	Y2H Prey Pooling	32296183
Intra	POU6F2	P78424	NUP62CL	Homo sapiens	Q9H1M0	Validated Y2H	32296183
Intra	POU6F2	P78424	TENT5B	Homo sapiens	Q96A09	Validated Y2H	32296183
Intra	POU6F2	P78424	EBF1	Homo sapiens	Q9UH73	Validated Y2H	32296183
Intra	POU6F2	P78424	SMYD1	Homo sapiens	Q8NB12	Validated Y2H	32296183
Intra	POU6F2	P78424	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	POU6F2	P78424	VPS9D1	Homo sapiens	Q9Y2B5	Validated Y2H	32296183
Intra	POU6F2	P78424	TTC23	Homo sapiens	Q5W5X9-3	Validated Y2H	32296183
Intra	POU6F2	P78424	GMEB2	Homo sapiens	Q9UKD1	Validated Y2H	32296183
Intra	POU6F2	P78424	TTC19	Homo sapiens	Q6DKK2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Wilms Tumor 5	Wilms Tumor WT5 Wilms Tumor Susceptibility-5 Wilms Tumor And Radial Bilateral Aplasia Nephroblastoma Wilms' Tumor Wilms Tumor, Susceptibility To Wtsl Bilateral Radial Aplasia With Wilms Tumor Embryonal Adenosarcoma Embryonal Nephroma Kidney Wilms Tumor Kidney, Adenomyosarcoma, Embryonal Kidney, Carcinosarcoma, Embryonal Kidney, Embryoma Kidney, Embryonal Mixed Tumor Nephroma Renal Adenosarcoma Renal Cancer, Wilms Renal Wilms Tumor Tumor, Wilms Hereditary Susceptibility To Wilms Tumor 5
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type	Wilson-Turner Syndrome WTS Mrxs6 X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome Mrxswt Wilson-Turner X-Linked Mental Retardation Syndrome Mental Retardation, X-Linked, Syndromic 6 Mental Retardation, X-Linked, With Gynecomastia And Obesity Intellectual Disability, X-Linked, Syndromic 6 Intellectual Disability, X-Linked, With Gynecomastia And Obesity Wilson Turner Intellectual Disability Syndrome X-Linked Intellectual Disability - Gynecomastia - Obesity
Syndromic X-Linked Intellectual Disability	X-Linked Syndromic Intellectual Disability
Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS10913	POU6F2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	POU6F2	VGNC	VGNC:76093
Rattus norvegicus	POU6F2	RGD	RGD:1584652
Felis catus	POU6F2	VGNC	VGNC:102664
Mus musculus	POU6F2	MGD	MGI:2443631
Others	POU6F2	NCBI