2. Gene
  3. STAC - SH3 and cysteine rich domain Gene

STAC - SH3 and cysteine rich domain Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as STAC1

Gene ID: 6769 | Gene type: protein coding

About STAC

Cytogenetic location: 3p22.3-p22.2 Genomic coordinates (GRCh38): 3:36,380,504-36,548,007 (from NCBI)

This gene has 8 transcripts (splice variants), 204 orthologues and 2 paralogues. Biased expression in prostate (RPKM 5.7), lung (RPKM 4.4) and 11 other tissues.

Summary

Predicted to enable transmembrane transporter binding activity. Predicted to be involved in positive regulation of protein localization to plasma membrane; positive regulation of voltage-gated Calcium Channel activity; and skeletal muscle contraction. Predicted to act upstream of or within cellular response to heat; muscle contraction; and regulation of voltage-gated Calcium Channel activity. Predicted to be located in T-tubule. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

STAC Products(2)

mRNA Protein Name
NM_001292049.2 NP_001278978.1 SH3 and cysteine-rich domain-containing protein isoform 2
NM_003149.3 NP_003140.1 SH3 and cysteine-rich domain-containing protein isoform 1

STAC Protein Structure

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (108 - 152)

SH3_1

SH3_1: SH3 domain (291 - 336)

SH3_2

SH3_2: Variant SH3 domain (349 - 400)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
Protein Preferred Names Protein Names

SH3 and cysteine-rich domain-containing protein

SRC homology 3 and cysteine-rich domain-containing protein

Related Diseases

Diseases Alias
Exudative Vitreoretinopathy 6

EVR6

Vitreoretinopathy, Exudative 6

Vitreoretinopathy, Exudative, Type 6
Myopathy, Congenital, Bailey-Bloch

Native American Myopathy

Nam

MYPBB

Myopathy, Congenital, Baily-Bloch

Anti-Hmg-Coa Myopathy

Anti-Srp Myopathy

Autoimmune Necrotizing Myositis

Imnm

Immune Myopathy With Myocyte Necrosis

Immune-Mediated Necrotizing Myopathy

Myopathy, Congenital, With Myopathic Facies, Scoliosis, And Malignant Hyperthermia

Necrotizing Autoimmune Myopathy

Congenital Myopathy-Cleft Palate-Malignant Hyperthermia Syndrome

Congenital Myopathy With Cleft Palate And Malignant Hyperthermia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16558 Butein 99.95% Unkown
HY-114981 SRTCX1002 Activator / Unkown
HY-RS13863 STAC Human Pre-designed siRNA Set A / Unkown
HY-RS13864 STAC2 Human Pre-designed siRNA Set A / Unkown
HY-RS13865 STAC3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus STAC RGD RGD:1305745
Bos taurus STAC VGNC VGNC:35350
Macaca mulatta STAC VGNC VGNC:77900
Canis familiaris STAC VGNC VGNC:46870
Mus musculus STAC MGD MGI:1201400
Felis catus STAC VGNC VGNC:65741
Others STAC NCBI