Nfe2l2 - nuclear factor, erythroid derived 2, like 2 Gene

Also Known as Nrf2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18024

About Nfe2l2

Chromosome 2: 75,505,857-75,534,985 reverse strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 218 orthologues, 3 paralogues and is associated with 92 phenotypes. Ubiquitous expression in bladder adult (RPKM 57.1), duodenum adult (RPKM 26.8) and 26 other tissues.

Summary

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. [provided by RefSeq, Sep 2015]

Nfe2l2 Products (2)

mRNA Protein Name
NM_001399226.1 NP_001386155.1 nuclear factor erythroid 2-related factor 2 isoform 2
NM_010902.5 NP_035032.1 nuclear factor erythroid 2-related factor 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables DNA binding IDA
IDA: Inferred from direct assay
12220541 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10037736 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
9240432 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10037736 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9240432 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9240432 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
9240432 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
17920186 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in PERK-mediated unfolded protein response IDA
IDA: Inferred from direct assay
14517290 MGI
involved in cell redox homeostasis IMP
IMP: Inferred from mutant phenotype
14978030 MGI
acts upstream of or within cellular response to copper ion IMP
IMP: Inferred from mutant phenotype
24462598 MGI
involved in cellular response to glucose starvation IMP
IMP: Inferred from mutant phenotype
14978030 MGI
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
9240432 MGI
acts upstream of or within cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
20978266 MGI
acts upstream of or within cellular response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
24486487 MGI
acts upstream of or within endoplasmic reticulum unfolded protein response IDA
IDA: Inferred from direct assay
14517290 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
24486487 MGI
involved in negative regulation of hematopoietic stem cell differentiation IMP
IMP: Inferred from mutant phenotype
23434824 MGI
involved in positive regulation of D-glucose import IDA
IDA: Inferred from direct assay
24024172 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14517290 MGI
acts upstream of or within positive regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
15087497 MGI
involved in positive regulation of blood coagulation IMP
IMP: Inferred from mutant phenotype
20978343 MGI
involved in positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
14978030 MGI
involved in positive regulation of glutathione biosynthetic process IMP
IMP: Inferred from mutant phenotype
14978030 MGI
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
20978343 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10037736 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24462598 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
14978030 MGI
acts upstream of or within reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
24866179 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12220541 MGI
acts upstream of or within regulation of embryonic development IGI
IGI: Inferred from genetic interaction
15087497 MGI
involved in regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
16585964 MGI
involved in regulation of removal of superoxide radicals IMP
IMP: Inferred from mutant phenotype
20978343 MGI
involved in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
14978030 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in chromatin IDA
IDA: Inferred from direct assay
20978343 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
14978030 MGI
located in cytoplasm IPI
IPI: Inferred from physical interaction
14517290 MGI
located in cytosol IDA
IDA: Inferred from direct assay
23043106 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14517290 MGI
part of protein-DNA complex IDA
IDA: Inferred from direct assay
14517290 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nfe2l2 Protein Structure

bZIP_NFE2-like

bZIP_NFE2-like: cd14720 (485 - 552)

bZIP_NFE2-like

bZIP_NFE2-like: cd14720 (486 - 548)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 597 a.a.
Protein Preferred Names Protein Names

nuclear factor erythroid 2-related factor 2

  • NF-E2-related factor 2

  • NFE2-related factor 2

Nfe2l2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Nfe2l2 Q60795 Keap1 Mus musculus Q9Z2X8
IF
38556546
Intra
Nfe2l2 Q60795 Keap1 Mus musculus Q9Z2X8
Anti Bait CoIP
38556546
Intra
Nfe2l2 Q60795 Keap1 Mus musculus Q9Z2X8
Pull Down
24366543
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-12213 CDDO-EA Activator 99.78% Unkown
HY-RS09245 NFE2L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09246 Nfe2l2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145390 Nrf2 activator-1 Activator 98.66% Unkown
HY-145390A (R,R)-Nrf2 activator-1 Activator 96.88% Unkown
HY-177944 DC-PGKI / Unkown
HY-RS09247 Nfe2l2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-125995 NFE2L2 activator 3 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfe2l2 NCBI NCBI:4780