PDE8A - phosphodiesterase 8A Gene

Also Known as HsT19550

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5151

About PDE8A

Cytogenetic location: 15q25.3 Genomic coordinates (GRCh38): 15:84,980,467-85,139,142 (from NCBI)

This gene has 16 transcripts (splice variants), 220 orthologues and 20 paralogues. Ubiquitous expression in colon (RPKM 9.5), kidney (RPKM 8.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

PDE8A Products (15)

mRNA Protein Name
XM_047432656.1 XP_047288612.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1
NM_001243137.2 NP_001230066.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 3
NM_173456.1
XM_011521668.3 XP_011519970.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X6
NM_173455.1
NM_173454.1 NP_775656.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 2
XM_047432659.1 XP_047288615.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X5
XM_047432658.1 XP_047288614.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3
XR_007064457.1
XM_047432657.1 XP_047288613.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2
XM_017022310.3 XP_016877799.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X4
XM_047432661.1 XP_047288617.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X8
XM_047432660.1 XP_047288616.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X7
NM_002605.3 NP_002596.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1
NM_173457.1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IMP
IMP: Inferred from mutant phenotype
9618252 GOA
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
9618252 GOA
enables kinase binding IPI
IPI: Inferred from physical interaction
23509299 GOA
enables protein kinase activator activity IMP
IMP: Inferred from mutant phenotype
23509299 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to epidermal growth factor stimulus IMP
IMP: Inferred from mutant phenotype
23509299 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
23509299 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE8A Protein Structure

Response_reg

Response_reg: Response regulator receiver domain (83 - 197)

PAS

PAS: PAS fold (219 - 324)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (555 - 809)

  • 0
  • 200
  • 400
  • 600
  • 829 a.a.
Protein Preferred Names Protein Names

high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

  • cAMP-specific cyclic nucleotide phosphodiesterase 8A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-15426 PF-04957325 Inhibitor 99.55% Unkown
HY-134937 BC8-15 Inhibitor / Unkown
HY-179503 PDE/TRPA1/CHIT1-IN-1 Inhibitor / Unkown
HY-RS10242 PDE8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10243 Pde8a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10244 Pde8a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PDE8A VGNC VGNC:44365
Bos taurus PDE8A VGNC VGNC:32687
Felis catus PDE8A VGNC VGNC:68766
Mus musculus PDE8A MGD MGI:1277116
Macaca mulatta PDE8A VGNC VGNC:75924
Rattus norvegicus PDE8A RGD RGD:735125
Others PDE8A NCBI