DOCK4 - dedicator of cytokinesis 4 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9732

About DOCK4

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:111,726,110-112,206,399 (from NCBI)

This gene has 18 transcripts (splice variants), 228 orthologues and 10 paralogues. Broad expression in lung (RPKM 9.6), brain (RPKM 9.0) and 23 other tissues.

Summary

This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]

DOCK4 Products (2)

mRNA	Protein	Name
NM_001363540.2	NP_001350469.1	dedicator of cytokinesis protein 4 isoform 2
NM_014705.4	NP_055520.3	dedicator of cytokinesis protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	16464467	GOA
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	16464467	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16464467	GOA
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	20679435	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	16464467	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	20679435	GOA
involved in negative regulation of vascular associated smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	22158624	GOA
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	22158624	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytosol	IDA IDA: Inferred from direct assay	20679435	GOA
located in membrane	IDA IDA: Inferred from direct assay	20679435	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOCK4 Protein Structure

SH3_2

DOCK-C2

DHR-2

0
400
800
1200
1600
1966 a.a.

Protein Preferred Names	Protein Names
dedicator of cytokinesis protein 4

DOCK4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	DOCK4	Q8N1I0	GRB2	Homo sapiens	P62993	Y2H	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Placenta Accreta
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Deafness, Autosomal Recessive 14	DFNB14 Autosomal Recessive Nonsyndromic Deafness 14 Autosomal Recessive Deafness 14
Dyslexia
Reading Disorder	Specific Reading Disorder Reading Dyslexia Developmental Reading Disorder
Deafness, Autosomal Recessive 17	DFNB17 Autosomal Recessive Nonsyndromic Deafness 17 Autosomal Recessive Deafness 17
Learning Disability	Learning Disabilities Learning Disorders Academic Skill Disorder Learning Disorder
Specific Language Impairment	Language Impairment, Specific

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS03926	DOCK4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DOCK4	VGNC	VGNC:71866
Canis familiaris	DOCK4	VGNC	VGNC:40048
Rattus norvegicus	DOCK4	RGD	RGD:1561724
Mus musculus	DOCK4	MGD	MGI:1918006
Bos taurus	DOCK4	VGNC	VGNC:28158
Felis catus	DOCK4	VGNC	VGNC:61573
Others	DOCK4	NCBI