HX009
Based on 1 Customer Validation
HX009 is a bispecific antibody targeting PD1 and CD47, but with weakened CD47 binding. HX009 blocks the functional of PD1/CD47. HX009 can be used for the study of non-Hodgkin’s lymphoma (NHL).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.56%
- Molecular Weight:173.16 kDa
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
Beschreibung
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
CD47 & PD-1
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Q61735-1 & Q02242
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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extracellular CD47-binding domain of human SIRPα protein at the C-terminus (Fc) of the heavy chain of HX008
Anwendung
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized human PD-1-His can bind HX009. The EC50 for this effect is 55.64 ng/mL. -
Immobilized human-CD47-His can bind HX009. The EC50 for this effect is 172.1 ng/mL.
Chemical Information
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Appearance Liquid
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Molecular Weight 173.16 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Versand
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (255 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)