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Art. -Nr.: HY-P992379

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IB001

(Synonyms: BAG3-H2L4)

IB001 is a humanized anti-BAG3 antibody that inhibits BAG3, with a K_D value of 14.4 nM for human BAG3. IB001 blocks BAG3-dependent monocyte/macrophage activation, interferes with the interaction between BAG3 and IFITM-2, and disrupts tumor microenvironment signaling pathways. IB001 inhibits tumor growth, reduces α-SMA-positive fibroblasts, and blocks BAG3-dependent IL-6 release. IB001 accumulates in a time-dependent manner in pancreatic ductal adenocarcinoma tumors. IB001 can be used for research related to pancreatic ductal adenocarcinoma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

IB001 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Species Reactivity

Human

IC₅₀ & Target^[1]

HSP70

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

In Vitro

IB001 (BAG3-H2L4) binds to purified recombinant human BAG3 protein with a K_d of 14.4 nM^[1].
IB001 inhibits binding of FITC-labeled recombinant human BAG3 to murine J774A.1 macrophage cells^[1].
IB001 (9.37-300 μg/mL; 16 h) dose-dependently inhibits recombinant human BAG3-induced IL-6 production by isolated human CD14⁺ monocytes^[1].
IB001 (200 μg/mL; 16 h) significantly inhibits PANC-1 pancreatic cancer cell conditioned medium-induced IL-6 production by isolated human CD14⁺ monocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

IB001 (BAG3-H2L4) (20 mg/kg; every 48 h; twice a week) induces significant pancreatic ductal adenocarcinoma tumor growth inhibition and reduces α-SMA-positive fibroblast abundance in tumor tissue in female CD-1 nu/nu mice^[1].
IB001 (20 mg/kg; daily; 7 days) does not induce cardiotoxicity in 6-month-old athymic nude-Foxn1 nu/nu mice after 7 days of daily treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD-1 nu/nu (female, 6 weeks old, injected with MIA PaCa-2 cells)^[1]
Dosage:

20 mg/kg
Administration:

every 48 h; twice a week
Result:

Achieved significant tumor growth inhibition, with final tumor volume reaching ~400% of initial volume compared to ~1000% in vehicle controls.
Reduced α-SMA-positive fibroblast area in tumor tissue from ~3.5% in vehicle-treated mice to <0.5%.

Animal Model:

Athymic nude-Foxn1 nu/nu (6 months old)^[1]
Dosage:

20 mg/kg
Administration:

daily; 7 days
Result:

Showed no adverse effect on ejection fraction, shortening fraction, or strain percentage.

Gene ID

9531 [NCBI]

Accession

O95817

Target

BAG3

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Anwendung

ELISA, FACS, Functional assay

Chemical Information

Synonyms

BAG3-H2L4
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Basile A, et al. Development of an anti-BAG3 humanized antibody for treatment of pancreatic cancer. Mol Oncol. 2019;13(6):1388-1399. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

IB001

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

IB001 Related Classifications

HY-P992379 Related Classifications