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Art. -Nr.: HY-119014

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NU-8231

NU-8231 (Compound 2) is a p53-MDM2 binding inhibitor with an IC₅₀ of 5.3-200 μM for inhibiting the p53-MDM2 interaction. NU-8231 is applicable for cancer research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 878022-36-7
Formel: C₂₆H₂₆ClNO₅
Molecular Weight:467.95

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

NU-8231 Chemical Structure

CAS. Nr.: 878022-36-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

NU-8231 (Compound 2) is a p53-MDM2 binding inhibitor with an IC₅₀ of 5.3-200 μM for inhibiting the p53-MDM2 interaction. NU-8231 is applicable for cancer research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
SJSA-1	IC₅₀	5.3 μM Compound: 2q	Inhibitory concentration against MDM2-p53 interaction in SJSA human sarcoma cells Inhibitory concentration against MDM2-p53 interaction in SJSA human sarcoma cells	[PMID: 15713419]

Chemical Information

CAS. Nr. 878022-36-7
Molecular Weight 467.95
Formel C₂₆H₂₆ClNO₅
SMILES

O=C1C=2C=CC=CC2C(OCC3=CC(OC)=C(O)C(OC)=C3)(C4=CC=C(Cl)C=C4)N1CCC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Beretta GL, et al. Small molecules targeting p53 to improve antitumor therapy. Mini Rev Med Chem. 2008;8(9):856-868. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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