Art. -Nr.: HY-B1741

3,6-Diaminoacridine

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

3,6-Diaminoacridine is a versatile acridine compound. 3,6-Diaminoacridine exerts antibacterial activity by intercalating into bacterial DNA, interfering with replication and transcription, and inducing bacterial lysis. 3,6-Diaminoacridine is an acridine dye and also a DNA intercalator.

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Reinheit: 98.78%
CAS. Nr.: 92-62-6
Formel: C₁₃H₁₁N₃
Molecular Weight:209.25

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

3,6-Diaminoacridine Chemical Structure

CAS. Nr.: 92-62-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.47 μM Compound: Acridine-3,6-diamine	Concentration required to inhibit the cell growth by 50 % after 96 hr A2780 leukemic cells. Concentration required to inhibit the cell growth by 50 % after 96 hr A2780 leukemic cells.	[PMID: 7658436]
A2780	IC₅₀	0.47 μM Compound: Proflavine	Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs	[PMID: 9371240]
A2780	IC₅₀	0.47 μM Compound: Proflavine	Compound was evaluated for cytotoxicity against A2780 cell lines. Compound was evaluated for cytotoxicity against A2780 cell lines.	10.1016/0960-894X(96)00130-8
A549	CC₅₀	3.1 μM Compound: 23	Cytotoxicity against human A549 cells expressing ACE2 assessed as cell viability Cytotoxicity against human A549 cells expressing ACE2 assessed as cell viability	[PMID: 35620927]
CHO	IC₅₀	0.52 μM Compound: 1	Phototoxicity in transformed CHO cells after 24 hrs of UV irradiation by WST1 assay Phototoxicity in transformed CHO cells after 24 hrs of UV irradiation by WST1 assay	[PMID: 19217190]
CHO	IC₅₀	1.1 μM Compound: 1	Phototoxicity in transformed CHO cells after 24 hrs incubation in dark by WST1 assay Phototoxicity in transformed CHO cells after 24 hrs incubation in dark by WST1 assay	[PMID: 19217190]
Keratinocyte	IC₅₀	>50 μM Compound: 1	Phototoxicity in normal human keratinocytes after 24 hrs incubation in dark by WST1 assay Phototoxicity in normal human keratinocytes after 24 hrs incubation in dark by WST1 assay	[PMID: 19217190]
Keratinocyte	IC₅₀	>50 μM Compound: 1	Phototoxicity in normal human keratinocytes after 24 hrs of UV irradiation by WST1 assay Phototoxicity in normal human keratinocytes after 24 hrs of UV irradiation by WST1 assay	[PMID: 19217190]
L1210	IC₅₀	2.7 μM Compound: Acridine-3,6-diamine	Concentration required to inhibit the cell growth by 50 % after 48 hr in L1210 leukemic cells. Concentration required to inhibit the cell growth by 50 % after 48 hr in L1210 leukemic cells.	[PMID: 7658436]
L1210	IC₅₀	2.7 μM Compound: Proflavine	Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs	[PMID: 9371240]
SK-MEL-2	IC₅₀	1.6 μM Compound: Proflavine	Cytotoxicity against human SK-MEL-2 cells expressing NRAS mutant assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human SK-MEL-2 cells expressing NRAS mutant assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 36961300]
SK-MEL-2	IC₅₀	5.31 μM Compound: Proflavine	Cytotoxicity against human SK-MEL-2 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay Cytotoxicity against human SK-MEL-2 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay	[PMID: 36961300]
THP-1	IC₅₀	2.21 μM Compound: proflavine	Cytotoxicity against human THP1 cells Cytotoxicity against human THP1 cells	[PMID: 17418916]
Vero	CC₅₀	3.4 μM Compound: 23	Cytotoxicity against African green monkey Vero cells assessed as cell viability Cytotoxicity against African green monkey Vero cells assessed as cell viability	[PMID: 35620927]

In Vitro

3,6-Diaminoacridine induces cytotoxicity in transformed Chinese hamster ovary cells, with an IC₅₀ of 1.1 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 92-62-6
Appearance Solid
Molecular Weight 209.25
Formel C₁₃H₁₁N₃
Color Light yellow to yellow
SMILES

NC1=CC2=NC3=CC(N)=CC=C3C=C2C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (3)

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Journal Impact Factor

EMBO Rep

CDK inhibitor Palbociclib targets STING to alleviate autoinflammation. [Abstract]

2022 Jun 7;23(6):e53932. PMID: 35403787
University of Pittsburgh

2025.
bioRxiv

SON-dependent nuclear speckle rehabilitation alleviates proteinopathies. [Abstract]

2025 Apr 28:2024.04.18.590103. PMID: 38659924

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (597.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.7790 mL

23.8949 mL

47.7897 mL

5 mM

0.9558 mL

4.7790 mL

9.5579 mL

10 mM

0.4779 mL

2.3895 mL

4.7790 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kubota Y, et al. Fluorescence decay studies of the DNA-3,6-diaminoacridine complexes. Biophys Chem. 1984;19(1):25-37. [Content Brief]

[2]. Gamage SA, et al. Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum. J Med Chem. 1994;37(10):1486-1494. [Content Brief]

[3]. Sabolova D, et al. Proflavine/acriflavine derivatives with versatile biological activities. J Appl Toxicol. 2020;40(1):64-71. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.7790 mL	23.8949 mL	47.7897 mL	119.4743 mL
	5 mM	0.9558 mL	4.7790 mL	9.5579 mL	23.8949 mL
	10 mM	0.4779 mL	2.3895 mL	4.7790 mL	11.9474 mL
	15 mM	0.3186 mL	1.5930 mL	3.1860 mL	7.9650 mL
	20 mM	0.2389 mL	1.1947 mL	2.3895 mL	5.9737 mL
	25 mM	0.1912 mL	0.9558 mL	1.9116 mL	4.7790 mL
	30 mM	0.1593 mL	0.7965 mL	1.5930 mL	3.9825 mL
	40 mM	0.1195 mL	0.5974 mL	1.1947 mL	2.9869 mL
	50 mM	0.0956 mL	0.4779 mL	0.9558 mL	2.3895 mL
	60 mM	0.0796 mL	0.3982 mL	0.7965 mL	1.9912 mL
	80 mM	0.0597 mL	0.2987 mL	0.5974 mL	1.4934 mL
	100 mM	0.0478 mL	0.2389 mL	0.4779 mL	1.1947 mL

Keywords

3,6-Diaminoacridine

3 Cited Publications

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3,6-Diaminoacridine

Publications Citing Use of MedChemExpress (MCE) 3,6-Diaminoacridine

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

3,6-Diaminoacridine Related Classifications

HY-B1741 Related Classifications