ANXA3 - annexin A3 Gene

Also Known as ANX3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 306

About ANXA3

Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:78,551,770-78,610,447 (from NCBI)

This gene has 10 transcripts (splice variants), 233 orthologues and 12 paralogues. Broad expression in bone marrow (RPKM 99.1), lung (RPKM 76.4) and 15 other tissues.

Summary

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]

ANXA3 Products (1)

mRNA Protein Name
NM_005139.3 NP_005130.1 annexin A3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent phospholipid binding IDA
IDA: Inferred from direct assay
2138016 GOA
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
15226301 GOA
Biological Process GO Annotation Evidence References Source
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
9497492 GOA
involved in neutrophil degranulation IDA
IDA: Inferred from direct assay
9550422 GOA
involved in phagocytosis IDA
IDA: Inferred from direct assay
9497492 GOA
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16236264 GOA
involved in positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
16236264 GOA
involved in positive regulation of endothelial cell migration IDA
IDA: Inferred from direct assay
16236264 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17205602 GOA
located in membrane IDA
IDA: Inferred from direct assay
17205602 GOA
located in phagocytic vesicle membrane IDA
IDA: Inferred from direct assay
7526843 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
7526843 GOA
located in specific granule IDA
IDA: Inferred from direct assay
7526843 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANXA3 Protein Structure

Annexin

Annexin: Annexin (23 - 87)

Annexin

Annexin: Annexin (94 - 159)

Annexin

Annexin: Annexin (177 - 243)

Annexin

Annexin: Annexin (255 - 317)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
Protein Preferred Names Protein Names

annexin A3

  • 35-alpha calcimedin

Recombinant ANXA3 Proteins

Cat. No. Product Name Accession Purity
HY-P7516 Annexin A3/ANXA3 Protein, Human P12429 (M1-D323) ≥ 90%, as determined by reducing SDS-PAGE.

ANXA3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810847 Annexin A3 Antibody WB, IHC-P Human, Mouse, Rat
HY-P86783 Annexin A3 Antibody (YA6476) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168951 (R)-SL18 Degrader / Unkown
HY-168950 ANXA3 degrader 1 Degrader / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ANXA3 MGD MGI:1201378
Felis catus ANXA3 VGNC VGNC:67699
Bos taurus ANXA3 VGNC VGNC:25965
Canis familiaris ANXA3 VGNC VGNC:37940
Rattus norvegicus ANXA3 RGD RGD:2119
Macaca mulatta ANXA3 VGNC VGNC:69948
Others ANXA3 NCBI