XEN-2174
XEN-2174 is a noradrenaline transporter (NET) inhibitor. XEN-2174 inhibits the reuptake of noradrenaline through non-competitive inhibition, increasing the concentration of noradrenaline in the synaptic cleft, thereby activating α2-adrenergic receptor at the spinal level and exerting analgesic effects. XEN-2174 exhibits long-lasting analgesic effects in models of neuropathic pain and postoperative pain in rats. XEN-2174 can be used in pain research.
For research use only. We do not sell to patients.
- CAS No.: 701909-57-1
- Formula: C58H85N17O16S4
- Molecular Weight:1404.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
Chemical Information
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CAS No. 701909-57-1
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Molecular Weight 1404.66
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Formula C58H85N17O16S4
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Sequence
{pGlu}-Gly-Val-Cys-Cys-Gly-Tyr-Lys-Leu-Cys-His-{Hyp}-Cys-NH2 (Disulfide bridge: Cys4-Cys13,Cys5-Cys10)
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Sequence Shortening
{pGlu}-GVCCGYKLCH-{Hyp}-C-NH2 (Disulfide bridge: Cys4-Cys13,Cys5-Cys10)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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