701909-57-1
Chemical Structure
XEN-2174
- CAS No.: 701909-57-1
- Formula:C58H85N17O16S4
- Molecular Weight:1404.66
IUPAC Name: (3R,8R,11R,17S,20S,23S,26R,29S,33R,34aS)-29-((1H-imidazol-5-yl)methyl)-20-(4-aminobutyl)-33-hydroxy-17-(4-hydroxybenzyl)-23-isobutyl-8-((S)-3-methyl-2-(2-((S)-5-oxopyrrolidine-2-carboxamido)acetamido)butanamido)-1,9,12,15,18,21,24,27,30-nonaoxodotriacontahydro-11,26-(methanodithiomethano)pyrrolo[2,1-g][1,2]dithia[5,8,11,14,17,20,23,26,29]nonaazacyclodotriacontine-3-carboxamide
InChIKey: FABZJQVOEXQFRZ-LRIIMAMNSA-N
SMILES: O=C1N2[C@](C[C@H](C2)O)([H])C(N[C@@H](CSSC[C@@H](C(N[C@@]3([H])CSSC[C@@](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC3=O)=O)CC4=CC=C(C=C4)O)=O)CCCCN)=O)CC(C)C)=O)([H])C(N[C@H]1CC5=CN=CN5)=O)=O)NC([C@H](C(C)C)NC(CNC([C@@H]6CCC(N6)=O)=O)=O)=O)C(N)=O)=O
Biological Activity: XEN-2174 is a noradrenaline transporter (NET) inhibitor. XEN-2174 inhibits the reuptake of noradrenaline through non-competitive inhibition, increasing the concentration of noradrenaline in the synaptic cleft, thereby activating α2-adrenergic receptor at the spinal level and exerting analgesic effects. XEN-2174 exhibits long-lasting analgesic effects in models of neuropathic pain and postoperative pain in rats. XEN-2174 can be used in pain research[1].
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XEN-2174 | XEN-2174 is a noradrenaline transporter (NET) inhibitor. XEN-2174 inhibits the reuptake of noradrenaline through non-competitive inhibition, increasing the concentration of noradrenaline in the synaptic cleft, thereby activating α2-adrenergic receptor at the spinal level and exerting analgesic effects. XEN-2174 exhibits long-lasting analgesic effects in models of neuropathic pain and postoperative pain in rats. XEN-2174 can be used in pain research. | |||||||||||||||||||||
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