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Cat. No.: HY-187802

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ATPase-IN-9

ATPase-IN-9 is an ATP synthase inhibitor. ATPase-IN-9 binds to the F₁ binding site of ATP synthase and inhibits its ATP hydrolytic activity. ATPase-IN-9 reduces intracellular ATP levels. ATPase-IN-9 can be used in research related to neurodegenerative diseases.

For research use only. We do not sell to patients.

Formula: C₁₉H₂₀N₂O₃
Molecular Weight:324.37

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Please store the product under the recommended conditions in the Certificate of Analysis.

ATPase-IN-9 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

ATPase-IN-9 (Compound 9a) (100 nM) inhibits ATP synthase hydrolytic activity in isolated mouse liver mitochondria with an IC₅₀ of 356.8 nM^[1].
ATPase-IN-9 (1 μM; 15 min) reduces cellular ATP levels by 24.53% in HT-22 mouse hippocampal neuronal cells when treated at 1 μM for 15 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

Molecular Weight 324.37
Formula C₁₉H₂₀N₂O₃
SMILES

CC1=CC=C(N2N(C(C3=CC=CC(OC)=C3)=O)CCC2=O)C(C)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Reichert L, et al. Identification of Pyrazolidine-3-One Derivatives as a Novel Structural Scaffold for ATP Synthase Inhibitors. ChemMedChem. 2026 Jul 29;21(14):e70399.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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