ztz240
Based on 1 Customer Validation
ztz240 is a chemical modulator of voltage-gated potassium channel Kv7 (KCNQ) (KCNQ2 and 3: EC50=6.1 μM; KCNQ4: EC50=12.2 μM). ztz240 can be used in analgesia and anti-epileptic research.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 325457-98-5
- Formula: C12H8ClFN2O
- Molecular Weight:250.66
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
KV7.2 6.1 μM (EC50) |
KV7.3 6.1 μM (EC50) |
KV7.4 12.2 μM (EC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
0.98 μM
Compound: 20
|
Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction by liquid scintillation counting
Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction by liquid scintillation counting
|
[PMID: 24900334] |
| CHO | IC50 |
66 μM
Compound: 20
|
Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction by liquid scintillation counting
Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction by liquid scintillation counting
|
[PMID: 24900334] |
Chemical Information
-
CAS No. 325457-98-5
-
Appearance Solid
-
Molecular Weight 250.66
-
Formula C12H8ClFN2O
-
Color White to off-white
-
SMILES
O=C(C1=CC=C(C=C1)F)NC2=CN=C(C=C2)Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (398.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (270 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9895 mL | 19.9473 mL | 39.8947 mL | 99.7367 mL |
| 5 mM | 0.7979 mL | 3.9895 mL | 7.9789 mL | 19.9473 mL | |
| 10 mM | 0.3989 mL | 1.9947 mL | 3.9895 mL | 9.9737 mL | |
| 15 mM | 0.2660 mL | 1.3298 mL | 2.6596 mL | 6.6491 mL | |
| 20 mM | 0.1995 mL | 0.9974 mL | 1.9947 mL | 4.9868 mL | |
| 25 mM | 0.1596 mL | 0.7979 mL | 1.5958 mL | 3.9895 mL | |
| 30 mM | 0.1330 mL | 0.6649 mL | 1.3298 mL | 3.3246 mL | |
| 40 mM | 0.0997 mL | 0.4987 mL | 0.9974 mL | 2.4934 mL | |
| 50 mM | 0.0798 mL | 0.3989 mL | 0.7979 mL | 1.9947 mL | |
| 60 mM | 0.0665 mL | 0.3325 mL | 0.6649 mL | 1.6623 mL | |
| 80 mM | 0.0499 mL | 0.2493 mL | 0.4987 mL | 1.2467 mL | |
| 100 mM | 0.0399 mL | 0.1995 mL | 0.3989 mL | 0.9974 mL |
ztz240 Related Classifications
HY-115823 Related Classifications
Powered by Bioz