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Referencia número: HY-113920

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Azumolene sodium

Name: Azumolene sodium
Brand: MedChemExpress
SKU: HY-113920
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(Synonyms: EU4093)

3 Cited Publications

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Azumolene sodium (EU4093) is an analog of Dantrolene (HY-12542) that inhibits malignant hyperthermia (MH) syndrome and intracellular Ca²⁺ homeostasis failure caused by Halothane (HY-B1010)/Succinylcholine. Azumolene sodium (0.5-2.0 mg/kg) reduces [Ca²⁺]i (from 207 nM to 38 nM) in MH-susceptible skeletal muscle following intramuscular injection.

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No. CAS: 105336-14-9
Fòrmula: C₁₃H₉BrN₄NaO₃
Peso molecular:372.13

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Azumolene sodium Chemical Structure

No. CAS: 105336-14-9

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Chemical Information

No. CAS 105336-14-9
Peso molecular 372.13
Fòrmula C₁₃H₉BrN₄NaO₃
SMILES

O=C1NC(CN1/N=C/C2=NC=C(C3=CC=C(Br)C=C3)O2)=O.[Na]
Synonyms

EU4093
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Nat Commun

Crystal structures of Ryanodine Receptor reveal dantrolene and azumolene interactions guiding inhibitor development. [Abstract]

2025 Nov 18;16(1):10110. PMID: 41253812
Cell Death Dis

Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats. [Abstract]

2023 May 13;14(5):325. PMID: 37179386
Small

Intranasal Zinc Oxide Nanoparticles Induce Neuronal PANoptosis via Microglial Pathway. [Abstract]

2025 Mar;21(12):e2408139. PMID: 40012250

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Pureza: 99.98%

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ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
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SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Allen P D, Lopez J R, Sanchez V, et al. EU 4093 decreases intracellular [Ca2+] in skeletal muscle fibers from control and malignant hyperthermia-susceptible swine[J]. Anesthesiology, 1992, 76(1): 132-138.

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Azumolene sodium

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