2. Others
  3. Biochemical Assay Reagents
  4. BCN-PEG6-OH

BCN-PEG6-OH is a neutralizing agent and anticoagulant inhibitor containing strained alkyne. BCN-PEG6-OH undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) click reaction with azido-Warfarin to generate an inactive product that can be rapidly cleared via the kidneys. In mice, BCN-PEG6-OH effectively reduces the anticoagulant activity of azido-Warfarin in a dose-dependent manner, normalizes prothrombin time, and exhibits no inherent anticoagulant or procoagulant effects when administered alone. BCN-PEG6-OH can be used for the research of drug-induced coagulopathy.

For research use only. We do not sell to patients.

BCN-PEG6-OH

BCN-PEG6-OH Chemical Structure

CAS No. : 2270844-08-9

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

BCN-PEG6-OH Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BCN-PEG6-OH is a neutralizing agent and anticoagulant inhibitor containing strained alkyne. BCN-PEG6-OH undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) click reaction with azido-Warfarin to generate an inactive product that can be rapidly cleared via the kidneys. In mice, BCN-PEG6-OH effectively reduces the anticoagulant activity of azido-Warfarin in a dose-dependent manner, normalizes prothrombin time, and exhibits no inherent anticoagulant or procoagulant effects when administered alone. BCN-PEG6-OH can be used for the research of drug-induced coagulopathy[1].

In Vivo

BCN-PEG6-OH (compound 9) (26-52 mg/kg; subcutaneous injection; 2 doses total at 24-hour intervals) dose-dependently neutralizes azido-Warfarin-induced anticoagulant activity in mice, is cleared via the kidneys, and restores prothrombin time (PT) to levels close to those of the vehicle control group[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL6N Mice (male, 8-12 weeks of age, drug-induced coagulopathy model via azido-Warfarin administration)[1]
Dosage: 26 mg/kg; 52 mg/kg
Administration: s.c.; 2 doses with 24-hour interval, 5 minutes after each i.p. injection of azido-Warfarin
Result: Reduced the PT fold change (relative to vehicle) from 3.61 (azido-Warfarin alone) to 2.39.
Reduced the PT fold change from 3.61 to 1.75, a level that was not significantly different from vehicle controls.
Led to in vivo formation of the inactive clicked product 10, with plasma concentrations of free azido-Warfarin dropping below the limit of detection within 60 minutes, and 95.3% of the clicked product recovered in urine indicating rapid renal clearance.
Molecular Weight

457.56

Formula

C23H39NO8
CAS No.
SMILES

C(OC(NCCOCCOCCOCCOCCOCCO)=O)[C@H]1[C@@]2([C@]1(CCC#CCC2)[H])[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

BCN-PEG6-OH Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BCN-PEG6-OH2270844-08-9Biochemical Assay Reagentsmicestrain-promoted alkyne-azide cycloadditionprothrombin timedrug-induced coagulopathypro-coagulant activityhuman plasmaanticoagulant activitySPAAC click reactionazido-Warfarinrenal clearanceInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BCN-PEG6-OH
Cat. No.:
HY-183649
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.