2270844-08-9
Chemical Structure
BCN-PEG6-OH
- CAS No.: 2270844-08-9
- Formula:C23H39NO8
- Molecular Weight:457.56
IUPAC Name: ((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)methyl (17-hydroxy-3,6,9,12,15-pentaoxaheptadecyl)carbamate
InChIKey: LBCGUBKAGJHDSR-KOUNCHBCSA-N
SMILES: C(OC(NCCOCCOCCOCCOCCOCCO)=O)[C@H]1[C@@]2([C@]1(CCC#CCC2)[H])[H]
Biological Activity: BCN-PEG6-OH is a neutralizing agent and anticoagulant inhibitor containing strained alkyne. BCN-PEG6-OH undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) click reaction with azido-Warfarin to generate an inactive product that can be rapidly cleared via the kidneys. In mice, BCN-PEG6-OH effectively reduces the anticoagulant activity of azido-Warfarin in a dose-dependent manner, normalizes prothrombin time, and exhibits no inherent anticoagulant or procoagulant effects when administered alone. BCN-PEG6-OH can be used for the research of drug-induced coagulopathy[1].
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BCN-PEG6-OH | BCN-PEG6-OH is a neutralizing agent and anticoagulant inhibitor containing strained alkyne. BCN-PEG6-OH undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) click reaction with azido-Warfarin to generate an inactive product that can be rapidly cleared via the kidneys. In mice, BCN-PEG6-OH effectively reduces the anticoagulant activity of azido-Warfarin in a dose-dependent manner, normalizes prothrombin time, and exhibits no inherent anticoagulant or procoagulant effects when administered alone. BCN-PEG6-OH can be used for the research of drug-induced coagulopathy. | |||||||||||||||||||||
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Keywords
