ELL-associated factor 2

Definition:

Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.

References:

[1]. Wuhan Xiao, et al. Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer. Cancer Res. 2003 Aug 1;63(15):4698-704. [Content Brief]

[2]. Federico Simone, et al. ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties. Blood. 2003 Mar 15;101(6):2355-62. [Content Brief]

[3]. Stephanie E Kong, et al. ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10094-8. [Content Brief]

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