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Cat. No.: HY-114721

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BTA-9881

(Synonyms: MEDI-564)

BTA-9881 (MEDI-564) is a RSV inhibitor, with an EC₅₀: 48 nM, 59 nM and 160 nM for RSV A2, RSV Long, and RSV B1. BTA-9881 has favorable pharmacokinetics property.

For research use only. We do not sell to patients.

CAS No.: 1646857-24-0
Formula: C₂₁H₁₅ClN₄O₂
Molecular Weight:390.82

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

BTA-9881 Chemical Structure

CAS No.: 1646857-24-0

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Biological Activity
- Description
- Cellular Effect
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

BTA-9881 (MEDI-564) is a RSV inhibitor, with an EC₅₀: 48 nM, 59 nM and 160 nM for RSV A2, RSV Long, and RSV B1. BTA-9881 has favorable pharmacokinetics property^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEp-2	EC₅₀	0.048 μM Compound: 33a	Antiviral activity against respiratory syncytial virus A2 infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay Antiviral activity against respiratory syncytial virus A2 infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 25595685]
HEp-2	EC₅₀	0.059 μM Compound: 33a	Antiviral activity against respiratory syncytial virus Long infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay Antiviral activity against respiratory syncytial virus Long infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 25595685]
HEp-2	EC₅₀	0.16 μM Compound: 33a	Antiviral activity against respiratory syncytial virus B1 infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay Antiviral activity against respiratory syncytial virus B1 infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 25595685]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1646857-24-0
Molecular Weight 390.82
Formula C₂₁H₁₅ClN₄O₂
SMILES

O=C1N2[C@@](C3=CC=C(C=C3)Cl)(N(CC2)C(C4=CC=CN=C4)=O)C5=C1C=CN=C5
Synonyms

MEDI-564
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bond S, et al. 1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: identification of BTA9881 as a preclinical candidate. Bioorg Med Chem Lett. 2015 Feb 15;25(4):976-81. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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