c-Met-IN-17

Cat. No.: HY-153831: FAQs
Data Sheet Handling Instructions

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c-Met-IN-17 is a potent c-Met kinase inhibitor with an IC₅₀ of 0.031 μM. c-Met-IN-17 can be used in anticancer research.. c-Met-IN-17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

c-Met-IN-17 Chemical Structure

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Description

c-Met-IN-17 is a potent c-Met kinase inhibitor with an IC₅₀ of 0.031 μM. c-Met-IN-17 can be used in anticancer research.^[1]. c-Met-IN-17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

C-met-in-17 (compound 29) inhibits D1228V c-Met enzyme activity with an IC₅₀ of 0.068 μM by ADP-Glo assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

c-Met-IN-17 (0.5 mg/kg; i.v.; 0-24 h) shows excellent bioavailability in Wistar Rats^[1].
In vivo pharmacokinetic analysis in Wistar Rats^[1]

Route	Dose (mg/kg)	Cl (mL/min/kg)	V_{ss_obs} (L/kg)	Bioavailability (%)
i.v.	0.5	60	4.6	100

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

374.37

Formula

C₂₁H₁₅FN₄O₂

SMILES

FC1=CC2=C(C(C3=CN(C(NC3=O)=O)C(C4=CC=CC=C4)C)=C1)NN=C2C#C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Michaelides IN, et al. Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J Med Chem. 2023 Jul 13;66(13):8782-8807. [Content Brief]

c-Met-IN-17 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

c-Met-IN-17c-Met/HGFRc-Met kinase inhibitorantitumor efficacyBBBInhibitorinhibitorinhibit

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