c-Met-IN-18
c-Met-IN-18 is ATP competitive type-III c-MET inhibitor of WT and D1228V mutant c-MET. c-Met-IN-18 has inhibitory for WT/D1228V with an IC50 value of 0.013/0.20e.c-Met-IN-18 can be used for the research of c-MET driven cancers. c-Met-IN-18 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- CAS No.: 3034863-56-1
- Formula: C21H15FN4O2
- Molecular Weight:374.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.013/0.20e (WT/D1228V)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H1993 | EC50 |
0.339 μM
Compound: 30
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Inhibition of c-MET D1228V in human NCI-H1993 cells incubated for 4 hrs by HTRF assay
Inhibition of c-MET D1228V in human NCI-H1993 cells incubated for 4 hrs by HTRF assay
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[PMID: 37343272] |
Chemical Information
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CAS No. 3034863-56-1
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Molecular Weight 374.37
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Formula C21H15FN4O2
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SMILES
O=C1NC(C(C2=CC(F)=CC3=C2NN=C3C#C)=CN1[C@H](C4=CC=CC=C4)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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