Ca(II)-EDTA disodium dihydrate
Based on 1 Customer Validation
CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis. CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 6766-87-6
- Formula: C10H12CaN2O8.2H2.2Na
- Molecular Weight:410.30
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
CaⅡ-EDTA disodium dehydrate (0-100 mM) inhibits growths of periodontopathic bacteria A. actinomycetemcomitans, P. intermedia and P. gingivalis, with MICs of 70, 70 and 60 mM, respectively[1].
CaⅡ-EDTA disodium dehydrate (0-1000 mM) exhibits cytotoxicity in L929 cells and a safe dose of 75 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Murine L929 cells
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Concentration:0-1000 mM
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Incubation Time:24 h
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Result:Reduced cell viability in a dose-dependent manner. Remained a survival rate of 93% at the concentration of 75 mM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley rats [2]
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Dosage:50 mg/kg/day
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Administration:p.o. for 4 weeks (three-day break after each four consecutive days of administration)
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Result:Increased the body weight compared to the Cd-intoxicated group.
Decreased in serum creatinine and cadmium concentration compared to the Cd-intoxicated group.
Showed a good radio-density of the skeleton.
Chemical Information
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CAS No. 6766-87-6
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Appearance Solid
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Molecular Weight 410.30
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Formula C10H12CaN2O8.2H2.2Na
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Color White to off-white
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SMILES
O=C1[O-][Ca+2]([N]2(C1)CC3=O)([O-]3)([O-]C4=O)([O-]5)[N](C4)(CC2)CC5=O.[2].[2].[Na+].O
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Synonyms
Calcium disodium EDTA dihydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 100 mg/mL (243.72 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (284 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[2]. Saleh SM, et al., Do Nanoparticles of Calcium Disodium EDTA Minimize the Toxic Effects of Cadmium in Female Rats? Biol Trace Elem Res. 2023 Sep 18. [Content Brief]
[3]. Saxena G, et al., Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats. J Biochem Mol Toxicol. 2004;18(4):221-33. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 2.4372 mL | 12.1862 mL | 24.3724 mL | 60.9310 mL |
| 5 mM | 0.4874 mL | 2.4372 mL | 4.8745 mL | 12.1862 mL | |
| 10 mM | 0.2437 mL | 1.2186 mL | 2.4372 mL | 6.0931 mL | |
| 15 mM | 0.1625 mL | 0.8124 mL | 1.6248 mL | 4.0621 mL | |
| 20 mM | 0.1219 mL | 0.6093 mL | 1.2186 mL | 3.0466 mL | |
| 25 mM | 0.0975 mL | 0.4874 mL | 0.9749 mL | 2.4372 mL | |
| 30 mM | 0.0812 mL | 0.4062 mL | 0.8124 mL | 2.0310 mL | |
| 40 mM | 0.0609 mL | 0.3047 mL | 0.6093 mL | 1.5233 mL | |
| 50 mM | 0.0487 mL | 0.2437 mL | 0.4874 mL | 1.2186 mL | |
| 60 mM | 0.0406 mL | 0.2031 mL | 0.4062 mL | 1.0155 mL | |
| 80 mM | 0.0305 mL | 0.1523 mL | 0.3047 mL | 0.7616 mL | |
| 100 mM | 0.0244 mL | 0.1219 mL | 0.2437 mL | 0.6093 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Ca(II)-EDTA disodium dihydrate Related Classifications
HY-W749867 Related Classifications
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