Ca(Ⅱ)-EDTA disodium dihydrate  (Synonyms: Calcium disodium EDTA dihydrate)

CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis^[1]. CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning^[2][3].

CaⅡ-EDTA disodium dehydrate (0-100 mM) inhibits growths of periodontopathic bacteria A. actinomycetemcomitans, P. intermedia and P. gingivalis, with MICs of 70, 70 and 60 mM, respectively^[1].
CaⅡ-EDTA disodium dehydrate (0-1000 mM) exhibits cytotoxicity in L929 cells and a safe dose of 75 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CaⅡ-EDTA disodium dehydrate (50 mg/kg, p.o. for 4 weeks) alleviates the toxic effects of cadmium on kidney and bone with preference to the nanoparticles form^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

410.30

C₁₀H₁₂CaN₂O₈.2H₂.2Na

6766-87-6

O=C1[O-][Ca+2]([N]2(C1)CC3=O)([O-]3)([O-]C4=O)([O-]5)[N](C4)(CC2)CC5=O.[2].[2].[Na+].O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Miura, T. et al., Ca (II)-EDTA shows antimicrobial activity against periodontopathic bacteria. Journal of Biomedical Science and Engineering, 5, 10-14.

  [2]. Saleh SM, et al., Do Nanoparticles of Calcium Disodium EDTA Minimize the Toxic Effects of Cadmium in Female Rats? Biol Trace Elem Res. 2023 Sep 18.  [Content Brief]

  [3]. Saxena G, et al., Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats. J Biochem Mol Toxicol. 2004;18(4):221-33.  [Content Brief]