S-2474

S-2474 is an inhibitor of COX-2 and 5-lipoxygenase, with IC₅₀s of 11 nM and 27 μM for COX-2 and COX-1^[1]. S-2474 prevents neurons from Aβ-induced cell death significantly in a concentration-dependent manner (IC₅₀ =26±12 nM). S-2474 (10 μM) completely inhibits Aβ(25-35)-induced neuronal cell death. S-2474 also shows neuroprotective effects in the Aβ(1-40)-induced neuronal cell death. S-2474 inhibits the PGD2 generation in a concentration dependent manner (IC₅₀=69.8±21.9 nM). S-2474 (10 μM) lowers the elevated level of PGD2 significantly and reduces radicals from Aβ(25-35)-treated neurons^[2]. S-2474 significantly prevents neurons from undergoing sPLA₂-IIA-induced cell death. S-2474 completely ameliorates sPLA₂-IIA-induced apoptotic features such as the condensation of chromatin and the fragmentation of DNA. Moreover, S-2474 significantly inhibits the sPLA₂-IIA-induced generation of PGD2. S-2474 inhibits sPLA₂-IIA-induced neuronal cell death in a concentration-dependent manner (IC₅₀ = 94 nM)^[3].

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