DOPE-PEG2000-BR2

DOPE-PEG2000-BR2: surface modification of liposomes and nanoparticles for cancer cell-selective intracellular drug delivery, achieving efficient uptake in cancer cells while sparing normal cells.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two oleoyl chains that anchors into lipid bilayers and promotes pH-responsive membrane fusion for intracellular cargo release;
(2) PEG2000; a hydrophilic polymer that provides steric stabilization, reduces opsonization and immune clearance, and extends circulation half-life;
(3) BR2 peptide; a cancer cell-selective cell-penetrating peptide derived from buforin 2 that preferentially penetrates cancer cells by exploiting the altered membrane composition (higher negatively charged phosphatidylserine exposure and ganglioside content) of cancer cells, enabling selective drug delivery to tumors while minimizing uptake by normal cells, thereby reducing side effects.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.