ADORA3 - adenosine A3 receptor Gene

Also Known as A3AR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 140

About ADORA3

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:111,499,429-111,503,633 (from NCBI)

This gene has 4 transcripts (splice variants), 272 orthologues and 3 paralogues. Broad expression in adrenal (RPKM 4.4), small intestine (RPKM 2.9) and 20 other tissues.

Summary

This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]

ADORA3 Products (3)

mRNA Protein Name
NM_000677.4 NP_000668.1 adenosine receptor A3 isoform A
NM_001302678.2 NP_001289607.1 adenosine receptor A3 isoform B
NM_001302679.2 NP_001289608.1 adenosine receptor A3 isoform C

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
27886186 GOA
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
27886186 GOA
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
27886186 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADORA3 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (29 - 282)

  • 0
  • 100
  • 200
  • 300
  • 318 a.a.
Protein Preferred Names Protein Names

adenosine receptor A3

Related Diseases

Diseases Alias
Exfoliation Syndrome

  • Pseudoexfoliation Glaucoma

  • Pseudoexfoliation Syndrome

  • Exfoliation Syndrome, Susceptibility To

  • XFS

  • Exfoliation Glaucoma

  • Xfg

  • Pseudoexfoliation Of The Lens

  • Pexg

  • Pexs

  • Exfoliative Syndrome

  • Glaucoma Capsulare

  • Pex

  • Pseudo-Exfoliation Syndrome
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Ischemia

  • Acute Coronary Syndrome
Myocardial Stunning
Dermatitis, Atopic, 7

  • ATOD7

  • Dermatitis, Atopic, Susceptibility To, 7

  • Atopic Dermatitis 7

  • Dermatitis, Atopic 7
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Stroke, Ischemic

  • Cerebral Infarction

  • Stroke

  • Ischemic Stroke

  • Cerebrovascular Accident

  • Cerebral Infarction, Susceptibility To

  • Stroke, Ischemic, Susceptibility To

  • Cerebral Infarct

  • Ischemic Stroke, Susceptibility To

  • Stroke, Susceptibility To

  • Cva - Cerebral Infarction

  • ISCHSTR

  • Ischemic Cerebrovascular Accident
Intraocular Pressure Quantitative Trait Locus

  • Glaucoma

  • IOPQTL

  • Glaucoma, Susceptibility To

  • Postinfectious Glaucoma

  • Glaucoma With Ocular Inflammation

  • Glaucoma Secondary To Eye Inflammation

  • Traumatic Glaucoma

  • Glaucoma With Concussion Of Globe

  • Glaucoma Due To Ocular Trauma

  • Glaucoma Associated With Ocular Trauma

  • Glaucoma Secondary To Drugs
Subacute Leukemia
Vasculogenic Impotence

  • Impotence, Vasculogenic
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00400 ADORA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00401 Adora3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00402 ADORA3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ADORA3 VGNC VGNC:54876
Mus musculus ADORA3 MGD MGI:104847
Canis familiaris ADORA3 VGNC VGNC:37668
Rattus norvegicus ADORA3 RGD RGD:2051
Felis catus ADORA3 VGNC VGNC:59650