Grin2a - glutamate receptor, ionotropic, NMDA2A (epsilon 1) Gene

Also Known as NR2A; GluN2A; NMDAR2A; GluRepsilon1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14811

Summary

Enables NMDA glutamate receptor activity and Calcium Channel activity. Involved in regulation of synaptic plasticity. Acts upstream of or within several processes, including excitatory postsynaptic potential; learning or memory; and long-term synaptic potentiation. Located in several cellular components, including glutamatergic synapse; synaptic membrane; and synaptic vesicle. Is integral component of postsynaptic density membrane. Part of NMDA selective glutamate receptor complex. Is expressed in several structures, including central nervous system; eye; hindlimb phalanx; intestine; and limb mesenchyme. Human ortholog(s) of this gene implicated in Huntington's disease; bipolar disorder; and schizophrenia. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A). [provided by Alliance of Genome Resources, Apr 2022]

Grin2a Products (1)

mRNA Protein Name
NM_008170.4 NP_032196.2 glutamate receptor ionotropic, NMDA 2A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to NMDA glutamate receptor activity IGI
IGI: Inferred from genetic interaction
1374164 MGI
enables NMDA glutamate receptor activity IGI
IGI: Inferred from genetic interaction
1377365 MGI
enables NMDA glutamate receptor activity IMP
IMP: Inferred from mutant phenotype
7816096 MGI
contributes to calcium channel activity IGI
IGI: Inferred from genetic interaction
1374164 MGI
enables calcium channel activity IMP
IMP: Inferred from mutant phenotype
11160454 MGI
enables monoatomic cation channel activity IMP
IMP: Inferred from mutant phenotype
8699248 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9003035 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion transport IGI
IGI: Inferred from genetic interaction
1374164 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
11160454 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
9147327 MGI
NOT acts upstream of or within detection of mechanical stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
16190898 MGI
acts upstream of or within directional locomotion IGI
IGI: Inferred from genetic interaction
8987814 MGI
acts upstream of or within dopamine metabolic process IMP
IMP: Inferred from mutant phenotype
11160454 MGI
acts upstream of or within excitatory postsynaptic potential IGI
IGI: Inferred from genetic interaction
8987814 MGI
acts upstream of or within excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
8699248 MGI
involved in glutamate receptor signaling pathway IDA
IDA: Inferred from direct assay
25645137 MGI
acts upstream of or within learning IMP
IMP: Inferred from mutant phenotype
9427357 MGI
acts upstream of or within learning or memory IMP
IMP: Inferred from mutant phenotype
9712642 MGI
acts upstream of or within locomotion IMP
IMP: Inferred from mutant phenotype
11160454 MGI
acts upstream of or within long-term synaptic potentiation IGI
IGI: Inferred from genetic interaction
20661302 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
16901514 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
9458051 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
12427824 MGI
acts upstream of or within negative regulation of protein catabolic process IGI
IGI: Inferred from genetic interaction
15317856 MGI
acts upstream of or within neurogenesis IMP
IMP: Inferred from mutant phenotype
12941447 MGI
acts upstream of or within positive regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
17803966 MGI
acts upstream of protein catabolic process IGI
IGI: Inferred from genetic interaction
15317856 MGI
acts upstream of or within protein localization to postsynaptic membrane IGI
IGI: Inferred from genetic interaction
15317856 MGI
acts upstream of or within protein localization to postsynaptic membrane IMP
IMP: Inferred from mutant phenotype
15317856 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
7816096 MGI
acts upstream of or within regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
16157280 MGI
involved in regulation of synaptic plasticity IDA
IDA: Inferred from direct assay
25645137 MGI
involved in regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
12427824 MGI
acts upstream of or within response to amphetamine IMP
IMP: Inferred from mutant phenotype
15731593 MGI
acts upstream of or within response to ethanol IMP
IMP: Inferred from mutant phenotype
11530236 MGI
acts upstream of or within response to wounding IGI
IGI: Inferred from genetic interaction
9512392 MGI
acts upstream of or within response to wounding IMP
IMP: Inferred from mutant phenotype
9822733 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
14750973 MGI
acts upstream of or within sensory perception of pain IMP
IMP: Inferred from mutant phenotype
10694228 MGI
acts upstream of or within serotonin metabolic process IMP
IMP: Inferred from mutant phenotype
11160454 MGI
acts upstream of or within sleep IMP
IMP: Inferred from mutant phenotype
12754515 MGI
acts upstream of or within startle response IGI
IGI: Inferred from genetic interaction
14985927 MGI
NOT acts upstream of or within startle response IMP
IMP: Inferred from mutant phenotype
9718984 MGI
acts upstream of or within startle response IMP
IMP: Inferred from mutant phenotype
11488959 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
7816096 MGI
Cellular Component GO Annotation Evidence References Source
part of NMDA selective glutamate receptor complex IPI
IPI: Inferred from physical interaction
7929101 MGI
located in cell surface IDA
IDA: Inferred from direct assay
17229826 MGI
located in cell surface IMP
IMP: Inferred from mutant phenotype
17229826 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
16814779 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19726645 MGI
located in membrane IDA
IDA: Inferred from direct assay
8840015 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
21558424 MGI
located in neuron projection IMP
IMP: Inferred from mutant phenotype
21558424 MGI
located in postsynapse IDA
IDA: Inferred from direct assay
33158444 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
21664258 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
19726645 MGI
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
12103442 MGI
located in presynaptic membrane IDA
IDA: Inferred from direct assay
16157280 MGI
located in synapse IDA
IDA: Inferred from direct assay
14622577 MGI
located in synaptic membrane IDA
IDA: Inferred from direct assay
26609151 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
20418887 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor ionotropic, NMDA 2A

  • N-methyl D-aspartate receptor subtype 2A

  • glutamate [NMDA] receptor subunit epsilon-1

Grin2a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Grin2a P35436 Dlg4 Mus musculus Q62108
Anti Tag CoIP
16332682
Intra
Grin2a P35436 Dlg4 Mus musculus Q62108
Anti Bait CoIP
31746486
Intra
Grin2a P35436 Dlg4 Mus musculus Q62108
Y2H
9647694
Intra
Grin2a P35436 Dlg4 Mus musculus Q62108
Crosslink
28713243
Intra
Grin2a P35436 Dlg4 Mus musculus Q62108
Anti Bait CoIP
19240213
Intra
Grin2a P35436 Dlg4 Mus musculus Q62108
Anti Bait CoIP
19243221
Intra
Grin2a P35436 Patj Mus musculus Q63ZW7
Y2H
9647694
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05804 GRIN2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180866 GRIN2A modulator-1 / Unkown
HY-RS21136 Grin2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27654 Grin2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grin2a NCBI NCBI:2903