HECTD4 - HECT domain E3 ubiquitin protein ligase 4 Gene
Also Known as HEEL; POTAGE; C12ord51; C12orf51
Species: Homo sapiens
About HECTD4
This gene has 16 transcripts (splice variants), 205 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 8.7), bone marrow (RPKM 7.2) and 25 other tissues.
Summary
Predicted to enable ubiquitin-protein transferase activity. Involved in glucose homeostasis and glucose metabolic process. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
HECTD4 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001109662.4 | NP_001103132.4 | probable E3 ubiquitin-protein ligase HECTD4 isoform 1 |
| NM_001388303.1 | NP_001375232.1 | probable E3 ubiquitin-protein ligase HECTD4 isoform 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
15161933 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in glucose homeostasis |
IMP
IMP: Inferred from mutant phenotype
|
23575436 | GOA |
| involved in glucose metabolic process |
IMP
IMP: Inferred from mutant phenotype
|
23575436 | GOA |
HECTD4 Protein Structure
HECT: HECT-domain (ubiquitin-transferase) (3934 - 4266)
- 0
- 700
- 1400
- 2100
- 2800
- 3500
- 4272 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
probable E3 ubiquitin-protein ligase HECTD4 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Bone Angioendothelial Sarcoma |
|
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| Noonan Syndrome 1 |
|
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | HECTD4 | VGNC | VGNC:62785 |
| Rattus norvegicus | HECTD4 | RGD | RGD:1309762 |
| Bos taurus | HECTD4 | VGNC | VGNC:106766 |
| Canis familiaris | HECTD4 | VGNC | VGNC:41644 |
| Macaca mulatta | HECTD4 | VGNC | VGNC:73245 |
| Mus musculus | HECTD4 | MGD | MGI:3647820 |
| Others | HECTD4 | NCBI |