1. Gene
  2. HECTD4 - HECT domain E3 ubiquitin protein ligase 4 Gene

HECTD4 - HECT domain E3 ubiquitin protein ligase 4 Gene

Homo sapiens

Also known as HEEL; POTAGE; C12ord51; C12orf51

Gene ID: 283450 | Gene type: protein coding

About HECTD4

This gene has 16 transcripts (splice variants), 205 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 8.7), bone marrow (RPKM 7.2) and 25 other tissues.

Summary

Predicted to enable ubiquitin-protein transferase activity. Involved in glucose homeostasis and glucose metabolic process. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

HECTD4 Products(2)

mRNA Protein Name
NM_001109662.4 NP_001103132.4 probable E3 ubiquitin-protein ligase HECTD4 isoform 1
NM_001388303.1 NP_001375232.1 probable E3 ubiquitin-protein ligase HECTD4 isoform 2

HECTD4 Protein Structure

HECT

HECT: HECT-domain (ubiquitin-transferase) (3934 - 4266)

  • 0
  • 700
  • 1400
  • 2100
  • 2800
  • 3500
  • 4272 a.a.
Protein Preferred Names Protein Names

probable E3 ubiquitin-protein ligase HECTD4

AF-1 specific protein phosphatase

Related Diseases

Diseases Alias
Bone Angioendothelial Sarcoma

Osseous Hemangiosarcoma

Bone Angiosarcoma

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus HECTD4 VGNC VGNC:62785
Rattus norvegicus HECTD4 RGD RGD:1309762
Bos taurus HECTD4 VGNC VGNC:106766
Canis familiaris HECTD4 VGNC VGNC:41644
Macaca mulatta HECTD4 VGNC VGNC:73245
Mus musculus HECTD4 MGD MGI:3647820