HECTD4 - HECT domain E3 ubiquitin protein ligase 4 Gene

Also Known as HEEL; POTAGE; C12ord51; C12orf51

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 283450

About HECTD4

This gene has 16 transcripts (splice variants), 205 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 8.7), bone marrow (RPKM 7.2) and 25 other tissues.

Summary

Predicted to enable ubiquitin-protein transferase activity. Involved in glucose homeostasis and glucose metabolic process. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

HECTD4 Products (2)

mRNA Protein Name
NM_001109662.4 NP_001103132.4 probable E3 ubiquitin-protein ligase HECTD4 isoform 1
NM_001388303.1 NP_001375232.1 probable E3 ubiquitin-protein ligase HECTD4 isoform 2
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
15161933 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
23575436 GOA
involved in glucose metabolic process IMP
IMP: Inferred from mutant phenotype
23575436 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HECTD4 Protein Structure

HECT

HECT: HECT-domain (ubiquitin-transferase) (3934 - 4266)

  • 0
  • 700
  • 1400
  • 2100
  • 2800
  • 3500
  • 4272 a.a.
Protein Preferred Names Protein Names

probable E3 ubiquitin-protein ligase HECTD4

  • AF-1 specific protein phosphatase

HECTD4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
HECTD4 Q9Y4D8 YWHAZ Homo sapiens P63104 15161933
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bone Angioendothelial Sarcoma
  • Osseous Hemangiosarcoma

  • Bone Angiosarcoma

Noonan Syndrome 1
  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus HECTD4 VGNC VGNC:62785
Rattus norvegicus HECTD4 RGD RGD:1309762
Bos taurus HECTD4 VGNC VGNC:106766
Canis familiaris HECTD4 VGNC VGNC:41644
Macaca mulatta HECTD4 VGNC VGNC:73245
Mus musculus HECTD4 MGD MGI:3647820
Others HECTD4 NCBI