Smarcd3 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Gene

Also Known as BAF60C; 1500001J14Rik; 2210409C08Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 66993

Summary

Predicted to enable several functions, including chromatin binding activity; nuclear receptor binding activity; and nuclear receptor coactivator activity. Acts upstream of or within several processes, including heart morphogenesis; neural retina development; and positive regulation of transcription, DNA-templated. Located in nucleus. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including cardiogenic plate; central nervous system; ear; genitourinary system; and skin. Orthologous to human SMARCD3 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3). [provided by Alliance of Genome Resources, Apr 2022]

Smarcd3 Products (1)

mRNA	Protein	Name
NM_025891.3	NP_080167.3	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15525990	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cardiac right ventricle formation	IMP IMP: Inferred from mutant phenotype	17519332	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	15525990	MGI
acts upstream of or within muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	15525990	MGI
involved in neural retina development	IEP IEP: Inferred from expression pattern	18816825	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15525990	MGI
acts upstream of or within regulation of protein binding	IDA IDA: Inferred from direct assay	15525990	MGI
acts upstream of or within secondary heart field specification	IMP IMP: Inferred from mutant phenotype	17519332	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of SWI/SNF complex	IDA IDA: Inferred from direct assay	29374058	MGI
part of SWI/SNF superfamily-type complex	IDA IDA: Inferred from direct assay	24335282	MGI
part of nBAF complex	IDA IDA: Inferred from direct assay	17640523	MGI
part of npBAF complex	IDA IDA: Inferred from direct assay	17640523	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18816825	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3	60 kDa BRG-1/Brm-associated factor subunit C BRG1-associated factor 60C mBAF60c

Smarcd3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Smarcd3	Q6P9Z1	Smarca4	Mus musculus	Q3TKT4	Pull Down	22068056
Intra	Smarcd3	Q6P9Z1	Smarca4	Mus musculus	Q3TKT4	Anti Bait CoIP	22068056
Intra	Smarcd3	Q6P9Z1	Rbpj	Mus musculus	P31266	Anti Tag CoIP	17210915
Intra	Smarcd3	Q6P9Z1	Rbpj	Mus musculus	P31266	Pull Down	17210915
Intra	Smarcd3	Q6P9Z1	Notch1	Mus musculus	Q01705	Anti Tag CoIP	17210915
Intra	Smarcd3	Q6P9Z1	Myod1	Mus musculus	P10085	Anti Tag CoIP	22068056
Intra	Smarcd3	Q6P9Z1	Myod1	Mus musculus	P10085	Pull Down	22068056
Intra	Smarcd3	Q6P9Z1	Myod1	Mus musculus	P10085	Anti Bait CoIP	22068056

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13414	SMARCD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22045	Smarcd3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28563	Smarcd3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smarcd3	NCBI	NCBI:6604