SMARCD3 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Gene

Also Known as Rsc6p; BAF60C; CRACD3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6604

About SMARCD3

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:151,238,780-151,277,149 (from NCBI)

This gene has 15 transcripts (splice variants), 225 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 23.8), heart (RPKM 18.1) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

SMARCD3 Products (3)

mRNA Protein Name
NM_001003801.2 NP_001003801.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform 2
NM_001003802.2 NP_001003802.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform 1
NM_003078.4 NP_003069.2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
14701856 GOA
enables nuclear receptor binding IPI
IPI: Inferred from physical interaction
14701856 GOA
enables nuclear receptor coactivator activity IMP
IMP: Inferred from mutant phenotype
17363140 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14701856 GOA
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
14701856 GOA
enables transcription coregulator binding IPI
IPI: Inferred from physical interaction
14701856 GOA
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
11726552 GOA
involved in neural retina development IEP
IEP: Inferred from expression pattern
18816825 GOA
involved in nucleosome disassembly IDA
IDA: Inferred from direct assay
8895581 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14701856 GOA
involved in positive regulation of neuroblast proliferation IDA
IDA: Inferred from direct assay
18816825 GOA
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17363140 GOA
Cellular Component GO Annotation Evidence References Source
part of SWI/SNF complex IDA
IDA: Inferred from direct assay
8804307 GOA
located in chromatin IDA
IDA: Inferred from direct assay
17363140 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17363140 GOA
part of npBAF complex IDA
IDA: Inferred from direct assay
18816825 GOA
located in nucleus IDA
IDA: Inferred from direct assay
14701856 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMARCD3 Protein Structure

SWIB

SWIB: SWIB/MDM2 domain (260 - 333)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 483 a.a.
Protein Preferred Names Protein Names

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

  • 60 kDa BRG-1/Brm-associated factor subunit C

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13414 SMARCD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22045 Smarcd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28563 Smarcd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SMARCD3 RGD RGD:1311869
Bos taurus SMARCD3 VGNC VGNC:34995
Macaca mulatta SMARCD3 VGNC VGNC:77655
Canis familiaris SMARCD3 VGNC VGNC:46539
Felis catus SMARCD3 VGNC VGNC:65473
Mus musculus SMARCD3 MGD MGI:1914243
Others SMARCD3 NCBI