CCNA2 - cyclin A2 Gene
Also Known as CCN1; CCNA
Species: Homo sapiens
About CCNA2
This gene has 1 transcript (splice variant), 236 orthologues, 18 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 15.5), lymph node (RPKM 14.7) and 20 other tissues.
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]
CCNA2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001237.5 | NP_001228.2 | cyclin-A2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables cyclin-dependent protein serine/threonine kinase regulator activity |
IDA
IDA: Inferred from direct assay
|
1312467 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
7630397 | GOA |
| enables protein domain specific binding |
IPI
IPI: Inferred from physical interaction
|
15024385 | GOA |
| enables protein kinase binding |
IPI
IPI: Inferred from physical interaction
|
1312467 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in G2/M transition of mitotic cell cycle |
IDA
IDA: Inferred from direct assay
|
1312467 | GOA |
| involved in Ras protein signal transduction |
IEP
IEP: Inferred from expression pattern
|
9054499 | GOA |
| involved in cell cycle G1/S phase transition |
IDA
IDA: Inferred from direct assay
|
1312467 | GOA |
| involved in post-translational protein modification |
IDA
IDA: Inferred from direct assay
|
11746698 | GOA |
| involved in regulation of DNA replication |
IMP
IMP: Inferred from mutant phenotype
|
17234884 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of cyclin A2-CDK2 complex |
IDA
IDA: Inferred from direct assay
|
1312467 | GOA |
| part of cyclin A2-CDK2 complex |
IPI
IPI: Inferred from physical interaction
|
12244298 | GOA |
| part of cyclin-dependent protein kinase holoenzyme complex |
IDA
IDA: Inferred from direct assay
|
1312467 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
1312467 | GOA |
| located in nucleoplasm |
IDA
IDA: Inferred from direct assay
|
8245034 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
1312467 | GOA |
CCNA2 Protein Structure
Cyclin_N: Cyclin, N-terminal domain (181 - 306)
Cyclin_C: Cyclin, C-terminal domain (309 - 426)
- 0
- 100
- 200
- 300
- 400
- 432 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cyclin-A2 |
|
CCNA2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CCNA2 | P20248 | CDKN1A | Homo sapiens | P38936 | 33961781 | |
|
Intra
|
CCNA2 | P20248 | CDKN1A | Homo sapiens | P38936 | 15890360 | |
|
Intra
|
CCNA2 | P20248 | CDKN1A | Homo sapiens | P38936 | 28514442 | |
|
Intra
|
CCNA2 | P20248 | CDK2 | Homo sapiens | P24941 | 26496610 | |
|
Intra
|
CCNA2 | P20248 | CDK2 | Homo sapiens | P24941 | 12941338 | |
|
Intra
|
CCNA2 | P20248 | CDK2 | Homo sapiens | P24941 | 8684460 | |
|
Intra
|
CCNA2 | P20248 | CDK2 | Homo sapiens | P24941 | 17254966 | |
|
Intra
|
CCNA2 | P20248 | CDK2 | Homo sapiens | P24941 | 33961781 | |
|
Intra
|
CCNA2 | P20248 | CDK2 | Homo sapiens | P24941 | 8756328 | |
|
Intra
|
CCNA2 | P20248 | CDK2 | Homo sapiens | P24941 | 18177895 | |
|
Intra
|
CCNA2 | P20248 | CDK2 | Homo sapiens | P24941 | 17254966 | |
|
Intra
|
CCNA2 | P20248 | CDK2 | Homo sapiens | P24941 | 15189033 | |
|
Intra
|
CCNA2 | P20248 | CDK2 | Homo sapiens | P24941 | 15890360 | |
|
Intra
|
CCNA2 | P20248 | CDK2 | Homo sapiens | P24941 | 16209941 | |
|
Intra
|
CCNA2 | P20248 | CDK2 | Homo sapiens | P24941 | 12244298 | |
|
Intra
|
CCNA2 | P20248 | CDK2 | Homo sapiens | P24941 | 15890360 | |
|
Intra
|
CCNA2 | P20248 | CDK2 | Homo sapiens | P24941 | 15239650 | |
|
Intra
|
CCNA2 | P20248 | CDKN1B | Homo sapiens | P46527 | 18177895 | |
|
Intra
|
CCNA2 | P20248 | CDKN1B | Homo sapiens | P46527 | 26496610 | |
|
Intra
|
CCNA2 | P20248 | CDKN1B | Homo sapiens | P46527 | 8684460 | |
|
Intra
|
CCNA2 | P20248 | CDKN1B | Homo sapiens | P46527 | 17254966 | |
|
Intra
|
CCNA2 | P20248 | CDKN1B | Homo sapiens | P46527 | 15890360 | |
|
Intra
|
CCNA2 | P20248 | CDKN1B | Homo sapiens | P46527 | 17254966 | |
|
Intra
|
CCNA2 | P20248 | CDKN1B | Homo sapiens | P46527 | 20596027 | |
|
Intra
|
CCNA2 | P20248 | CDKN1B | Homo sapiens | P46527 | 15890360 | |
|
Intra
|
CCNA2 | P20248 | CDKN1B | Homo sapiens | P46527 | 16209941 | |
|
Intra
|
CCNA2 | P20248 | CDKN1B | Homo sapiens | P46527 | 33961781 | |
|
Intra
|
CCNA2 | P20248 | CDKN1B | Homo sapiens | P46527 | 17254966 | |
|
Intra
|
CCNA2 | P20248 | CDKN1B | Homo sapiens | P46527 | 15890360 | |
|
Intra
|
CCNA2 | P20248 | CDKN1B | Homo sapiens | P46527 | 28514442 | |
|
Cross
|
CCNA2 | P20248 | lt_sv40 | Simian virus 40 | P03070 | 8411358 | |
|
Intra
|
CCNA2 | P20248 | UHRF2 | Homo sapiens | Q96PU4 | 21952639 | |
|
Cross
|
CCNA2 | P20248 | E7 | Human papillomavirus | P03129 | 16061792 |
CCNA2 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80096 | Cyclin A2 Antibody (YA487) | WB, ICC/IF, IHC-P | Human, Mouse, Rat |
| HY-P83591 | Cyclin A2 Antibody (YA3336) | WB, IP | Human |
| HY-P83591A | Cyclin A2 Antibody (YA3336)(PBS only) | WB, IP | Human |
| HY-P84166 | Cyclin A2 Antibody (YA3863) | WB, IHC-P, FC, ELISA | Human |
| HY-P84166A | Cyclin A2 Antibody (YA3863)(PBS only) | WB, IHC-P, FC, ELISA | Human |
| HY-P86489 | Cyclin A2 Antibody (YA6181) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Retinoblastoma |
|
|
| Adenocarcinoma |
|
|
| Embryonal Carcinoma |
|
|
| Benign Meningioma |
|
|
| Pancreatic Adenocarcinoma |
|
|
| Lung Cancer |
|
|
| Colorectal Cancer |
|
|
| Breast Cancer |
|
|
| Squamous Cell Carcinoma |
|
|
| Focal Segmental Glomerulosclerosis |
|
|
| Colon Adenocarcinoma |
|
|
| Apocrine Adenosis Of Breast |
|
|
| Laryngeal Squamous Cell Carcinoma |
|
|
| Ovarian Cancer |
|
|
| B-Cell Lymphoma |
|
|
| Prostate Cancer |
|
|
| Pancreatic Cancer |
|
|
| Hepatocellular Carcinoma |
|
|
| Bladder Cancer |
|
|
| Cervical Cancer |
|
|
| Retinal Cancer |
|
|
| Endometrial Cancer |
|
|
| Pheochromocytoma |
|
|
| Ocular Cancer |
|
|
| Testicular Cancer |
|
|
| Gastric Cancer |
|
|
| Vascular Disease |
|
|
| Melanoma |
|
|
| Osteogenic Sarcoma |
|
|
| Meier-Gorlin Syndrome 5 |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Retinal Disease |
|
|
| Neuroblastoma |
|
|
| Esophageal Cancer |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Eye Disease |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Leukemia, Acute Myeloid |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | CCNA2 | VGNC | VGNC:70719 |
| Rattus norvegicus | CCNA2 | RGD | RGD:621059 |
| Bos taurus | CCNA2 | VGNC | VGNC:26957 |
| Felis catus | CCNA2 | VGNC | VGNC:78464 |
| Canis familiaris | CCNA2 | VGNC | VGNC:38893 |
| Mus musculus | CCNA2 | MGD | MGI:108069 |
| Others | CCNA2 | NCBI |