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Cat. No.: HY-153517

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hRVs-IN-1

hRVs-IN-1 (Compound 6g) is a selective anti-hRV viral agent. hRVs-IN-1 inhibits the replication of tested hRV strains with EC₅₀ values of 0.083, 0.078, and 0.015 μM against hRV-B14, hRV-A21, and hRV-A71, respectively. hRVs-IN-1 inhibits the replication of PV3 with an EC₅₀ of 0.063 μM.

For research use only. We do not sell to patients.

CAS No.: 2104030-01-3
Formula: C₂₀H₂₀N₂O₄S
Molecular Weight:384.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

hRVs-IN-1 Chemical Structure

CAS No.: 2104030-01-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
H1-HeLa	CC₅₀	18.1 μM Compound: 6g	Cytotoxicity against human H1HeLa cells assessed as decrease in cell viability after 3 days by MTT assay Cytotoxicity against human H1HeLa cells assessed as decrease in cell viability after 3 days by MTT assay	[PMID: 28581749]
HeLa	CC₅₀	9.6 μM Compound: 6g	Cytotoxicity aganist human HeLa cells assessed as decrease in cell viability after 2 days by MTT assay Cytotoxicity aganist human HeLa cells assessed as decrease in cell viability after 2 days by MTT assay	[PMID: 28581749]
HeLa	EC₅₀	0.063 μM Compound: 6g	Antiviral activity against Human poliovirus 3 infected in human HeLa cells assessed as protection against virus induced cytopathic effect after 2 days by MTT assay Antiviral activity against Human poliovirus 3 infected in human HeLa cells assessed as protection against virus induced cytopathic effect after 2 days by MTT assay	[PMID: 28581749]

In Vitro

hRVs-IN-1 (3 days) potently inhibits replication of hRV-B14, hRV-A21, and hRV-A71 in H1HeLa cells with EC₅₀ values of 0.083, 0.078, and 0.015 μM, respectively, and high selectivity indices ranging from 220 to 1200^[1].
hRVs-IN-1 (2 days) potently inhibits replication of PV3 in HeLa cells with an EC₅₀ of 0.063 μM and a selectivity index of 150^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2104030-01-3
Molecular Weight 384.45
Formula C₂₀H₂₀N₂O₄S
SMILES

O=C(OC(C)C)C=1SC=2C=C(OC=3C=CN=C(C3)C(=O)NC)C=CC2C1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kim J, et al. A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication. J Med Chem. 2017;60(13):5472-5492. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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