N-Methylmoranoline
N-Methylmoranoline (MOR 14) is an α-glucosidase inhibitor.
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- Pureté : 99.0%
- CAS No.: 69567-10-8
- Formule: C7H15NO4
- Masse moléculaire:177.20
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLT-4 | CC50 |
>100 mg/mL
Compound: 2
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Concentration giving 50% inhibition of growth of mock-infected MOLT-4 cells
Concentration giving 50% inhibition of growth of mock-infected MOLT-4 cells
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[PMID: 7608901] |
| MOLT-4 | EC50 |
100 mg/mL
Compound: 2
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Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MOLT-4 cells
Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MOLT-4 cells
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[PMID: 7608901] |
| MT4 | CC50 |
>100 mg/mL
Compound: 2
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Concentration giving 50% inhibition of growth of mock-infected MT-4 cells
Concentration giving 50% inhibition of growth of mock-infected MT-4 cells
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[PMID: 7608901] |
| MT4 | EC50 |
69 mg/mL
Compound: 2
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Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MT-4 cells
Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MT-4 cells
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[PMID: 7608901] |
In Vitro
N-Methylmoranoline dose-dependently decreases the α-1,6-glucosidase activity in rabbit heart extract. The myocardial uptake of a considerable amount of N-Methylmoranoline is sufficient to fully inhibit alpha-1,6-glucosidase. Preischemic treatment with 25, 50, and 100 mg/kg of N-Methylmoranoline dose-dependently reduces the infarct size without altering the blood pressure or heart rate[1]. MOR-14 significantly increases levels of PKC-ε in the particulate fraction at 20 and 30 min of ischaemia and in the cytosolic fraction at 30 min of ischaemia[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 69567-10-8
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Appearance Solid
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Masse moléculaire 177.20
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Formule C7H15NO4
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Color White to off-white
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SMILES
O[C@@H]1[C@@H](CO)N(C)C[C@H](O)[C@H]1O
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Synonyms
MOR 14; N-Methyl-1-deoxynojirimycin; N-Methylmoranolin
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Arai M, et al. N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly reduced infarct size in rabbit hearts. Circulation. 1998 Apr 7;97(13):1290-7. [Content Brief]
[2]. Arai M, et al. Role of protein kinase C in the reduction of infarct size by N-methyl-1-deoxynojirimycin, an alpha-1,6-glucosidase inhibitor. Br J Pharmacol. 2001 Jul;133(5):635-42. [Content Brief]
[3]. Nishida Y, et al. N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction. Heart Vessels. 2000;15(6):268-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N-Methylmoranoline Related Classifications
HY-U00090 Related Classifications
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