SA 47
Based on 1 publication(s) in Google Scholar
SA 47 is a selective fatty acid amide hydrolase (FAAH) inhibitor. SA 47 inhibits FAAH enzyme activity and disrupts the NLRP3-FAAH interaction, promoting K48 ubiquitination and selective autophagic degradation of NLRP3. SA 47 reduces NLRP3 protein levels in macrophages. SA 47 can be used for research on inflammatory diseases associated with NLRP3 protein mutations.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.0%
- CAS No.: 792236-07-8
- Formule: C17H26N4O3
- Masse moléculaire:334.41
-
Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-14380
PF-3845FAAH Inhibitor -
HY-15250
JZL195Dual FAAH/MAGL Inhibitor -
HY-10864
URB-597FAAH Inhibitor -
HY-79511
FAAH-IN-2FAAH Inhibitor -
HY-19636
JNJ-42165279FAAH Inhibitor -
HY-14376
RedafamdastatFAAH Inhibitor -
HY-10865
LY2183240Anandamide Uptake/FAAH Inhibitor -
HY-18081
PF 750FAAH Inhibitor -
HY-19740
BIA 10-2474FAAH Inhibitor -
HY-10862
FAAH inhibitor 1FAAH Inhibitor -
HY-N2365
Macamide BFAAH Inhibitor -
HY-79511R
FAAH-IN-2 (Standard)FAAH Inhibitor
Publications Citing Use of MedChemExpress (MCE) SA 47
More
Activité biologique
Description
IC50 & Target
FAAH, Carbamate[1].
In Vitro
SA 47 (40 μM) induces NLRP3 protein degradation in BMDMs, reducing NLRP3 protein levels by more than 30%[1].
SA 47 (10 μM; 30 min) does not inhibit any of the seven cloned rat carboxylesterases in HEK293T cells (X51974/TGH/ES10, NM_031565/ES3, NM_133586/ES2, NM_144743, NM_017004, X81825/ES4, and NM_001024365)[2].
SA 47 (10 μM; 30 min) does not significantly inhibit carboxylesterase activity in rat liver microsomes or cytosol[2].
SA 47 shows excellent selectivity for FAAH in both mouse and human tissues, with no significant off-target effects at 10 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 792236-07-8
-
Appearance Solid
-
Masse moléculaire 334.41
-
Formule C17H26N4O3
-
Color White to off-white
-
SMILES
CNC(COC(NCCC(CC1)CCN1C2=CC=CC(C)=N2)=O)=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Cell Death Differ
FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system. [Abstract]2023 Jan;30(1):168-183. PMID: 36104448
Protocole
-
Autophagy
Autophagy is a process in which eukaryotic cells use lysosomes to degrade their own cytoplasmic proteins and damaged organelles under the regulation of autophagy related gene (Atg). Microtubule-associated proteins light chain 3 (LC3) is recognized as autophagy marker, which transfers from cytoplasmic LC3 (LC3-I) to membrane type (LC3-II). LC3-II/I ratio could be detected by Western Blot and fluorescence microscopy.
Pureté et documentation
-
Fiche technique (268 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SA 47 Related Classifications
HY-18080 Related Classifications
Powered by Bioz