AAA-10 formic
Based on 1 publication(s) in Google Scholar
AAA-10 formic is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC50s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH, respectively.
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- Formule: C26H43FO7S
- Masse moléculaire:518.68
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Publications Citing Use of MedChemExpress (MCE) AAA-10 formic
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Activité biologique
IC50: 10 nM (B. theta rBSH), 80 nM (B. longum rBSH)[1]
AAA-10 (100 μM; 24 h) formic inhibits BSH activity in bacterial cultures, with IC50s of 74 nM, 901 nM for Gram-negative and Gram-positive bacteria, respectively[1].
AAA-10 (20 μM; 2 h) formic significantly inhibits deconjugation of glycochenodeoxycholic acid-d4 or taurocholic acid-d4 substrates of human feces[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AAA-10 (30 mg/kg) formic displays high colonic exposure and low gut permeability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:10-11 weeks old male C57Bl/6J mice[1]
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Dosage:30 mg/kg
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Administration:Orally gavaged once daily for 5 days
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Result:Decreased the abundances of DCA and LCA in mice feces starting in day 2-5.
Displayed high colonic exposure and low gut permeability.
Chemical Information
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Masse moléculaire 518.68
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Formule C26H43FO7S
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SMILES
C[C@H](CCC(CF)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](OS(=O)(O)=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.O=CO
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Host Microbe
Metabolic immaturity and breastmilk bile acid metabolites are central determinants of heightened newborn vulnerability to norovirus diarrhea. [Abstract]2024 Aug 21:S1931-3128(24)00290-7. PMID: 39214086
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AAA-10 formic Related Classifications
HY-145147A Related Classifications
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