AChE-IN-21
AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC50 of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro.
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- CAS No.: 2413656-04-7
- Formule: C24H29NO4
- Masse moléculaire:395.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
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EeAChE 2.66 nM (IC50) |
RatBuChE 19.10 μM (IC50) |
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming mice at body weight of 18–22 g (male and female in half)[1]
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Dosage:1.0, 5.0 and 25.0 mg/kg
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Administration:Intragastric administration, once a day for 7 consecutive days
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Result:Obviously blocked scopolamine (2 mg/kg, i.p.)-induced memory deficit.
Chemical Information
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CAS No. 2413656-04-7
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Masse moléculaire 395.49
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Formule C24H29NO4
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SMILES
O=C1O/C(C2=C1C=C(OC)C(OC)=C2)=C\CCCCCN(CC3=CC=CC=C3)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-21 Related Classifications
HY-150545 Related Classifications
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