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Cat. No.: HY-209461

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Aib-Aib

Aib-Aib is a dipeptide compound formed by the condensation of two non-proteinogenic α-aminoisobutyric acid residues. Aib-Aib confers strong resistance to proteolytic degradation as a core component of natural peptaibols. Aib-Aib strongly induces and locks the peptide backbone into stable helical conformations through the massive steric hindrance of its dimethyl groups. Aib-Aib is widely used as a critical structural building block in long-acting peptide drug design, solid-phase synthesis optimization, and self-assembling bionanomaterial research.

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CAS No.: 39692-70-1
Formule: C₈H₁₆N₂O₃
Masse moléculaire:188.22

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Synthèse personnalisée de peptides

Aib-Aib Chemical Structure

CAS No.: 39692-70-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Chemical Information

CAS No. 39692-70-1
Masse moléculaire 188.22
Formule C₈H₁₆N₂O₃
Sequence

Aib-Aib
Sequence Shortening

Aib-Aib
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Rajagopal A, et al. Chain length effects on helix-hairpin distribution in short peptides with Aib-DAla and Aib-Aib segments. Biopolymers. 2011;96(6):744-56.

[2]. Schweitzer-Stenner R, et al. Conformational manifold of alpha-aminoisobutyric acid (Aib) containing alanine-based tripeptides in aqueous solution explored by vibrational spectroscopy, electronic circular dichroism spectroscopy, and molecular dynamics simulations. Journal of the American Chemical Society. 2007 Oct 31;129(43):13095-109.

[3]. Salnikov ES, et al. Structure and alignment of the membrane-associated peptaibols ampullosporin A and alamethicin by oriented 15N and 31P solid-state NMR spectroscopy. Biophys J. 2009 Jan;96(1):86-100.

[4]. Lau J, et al. Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide. Journal of medicinal chemistry. 2015 Sep 24;58(18):7370-80. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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