Albicidin
Albicidin is a peptide antibiotic with phytotoxic activity. Albicidin potently inhibits bacterial and plant DNA gyrase at nanomolar concentrations, blocks DNA replication, and exhibits excellent antibacterial efficacy against multidrug-resistant bacteria. Albicidin possesses bactericidal activity against Gram-positive and Gram-negative microorganisms, and acts as a virulence factor for the systemic plant infection by Xanthomonas albilineans. Albicidin can be used in studies related to bacterial infections and sugarcane leaf blight.
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- CAS No.: 1622253-00-2
- Formule: C44H38N6O12
- Masse moléculaire:842.81
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
IC50 & Target
[1]|
DNA Gyrase |
In Vitro
Albicidin (30-200 nM) inhibits the DNA gyrase supercoiling activity of E. coli, with an IC50 of approximately 40 nM[1].
Albicidin exhibits potent antibacterial activity against Escherichia coli (including fluoroquinolone-resistant strains), Salmonella enteritidis, Pseudomonas aeruginosa, Staphylococcus aureus, and Micrococcus luteus, with MIC values ranging from 0.031 to 16 μg/mL[1].
Albicidin (0-3200 nM; 30-60 min) inhibits DNA supercoiling mediated by wild-type E. coli DNA gyrase, with an IC50 of 40 nM[2].
Albicidin (0-1600 nM; 30-60 min) inhibits the DNA supercoiling activity of mitochondrial and chloroplast DNA gyrases in Arabidopsis thaliana, with an IC50 of 50 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1622253-00-2
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Masse moléculaire 842.81
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Formule C44H38N6O12
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SMILES
O=C(C1=C(C(OC)=C(C=C1)NC(C2=CC=C(C=C2)NC([C@H](CC#N)NC(C3=CC=C(C=C3)NC(/C(C)=C/C4=CC=C(C=C4)O)=O)=O)=O)=O)O)NC5=C(C(O)=C(C=C5)C(O)=O)OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Kretz J, et al. Total synthesis of albicidin: a lead structure from Xanthomonas albilineans for potent antibacterial gyrase inhibitors. Angew Chem Int Ed Engl. 2015;54(6):1969-1973. [Content Brief]
[2]. Hashimi SM, et al. The phytotoxin albicidin is a novel inhibitor of DNA gyrase. Antimicrob Agents Chemother. 2007;51(1):181-187. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Albicidin Related Classifications
HY-108988 Related Classifications
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Keywords