AMBA
AMBA is a gastrin-releasing peptide receptor (GRPR, BB2, BRS-2) ligand. AMBA binds to GRPR with high specificity and high affinity, and undergoes receptor-mediated endocytosis, which retains the conjugated radiometal in target cells. AMBA is applicable for the research of prostate cancer.
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- CAS No.: 721937-56-0
- Formule: C68H99N19O18S
- Masse moléculaire:1502.70
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
AMBA (0.001-1000 nmol/L; 60 min) exhibits high specificity and nanomolar affinity for human GRPR receptors, with an IC50 of 0.82 nmol/L and a Ki of 0.65nmol/L[1].
AMBA (6.66 × 10-4 μmol (1 μg); 10 min) can be efficiently radiolabeled with 111In, achieving a radiolabeling efficiency of 95.43% under the tested conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 721937-56-0
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Masse moléculaire 1502.70
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Formule C68H99N19O18S
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Sequence
{DOTA}-Gly-{PAB}-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
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Sequence Shortening
{DOTA}-G-{PAB}-QWAVGHLM-NH2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AMBA Related Classifications
HY-P11768 Related Classifications
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