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Cat. No.: HY-124052

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AZ-27

AZ-27 is a respiratory syncytial virus (RSV) inhibitor. AZ-27 can differentially suppress various RSV polymerase activities at the promoter, thereby inhibiting the early stages of mRNA transcription and genome replication by targeting the promoter.

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CAS No.: 1516772-44-3
Formule: C₃₆H₃₅N₅O₄S
Masse moléculaire:633.76

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

AZ-27 Chemical Structure

CAS No.: 1516772-44-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BHK-21	EC₅₀	0.01 μM Compound: 11f	Antiviral activity against Respiratory syncytial virus A2 infected in hamster BHK21 cells after 2 days by luciferase reporter gene assay Antiviral activity against Respiratory syncytial virus A2 infected in hamster BHK21 cells after 2 days by luciferase reporter gene assay	[PMID: 24211022]
HEp-2	CC₅₀	>50 μM Compound: 11f	Cytotoxicity against human Hep2 cells Cytotoxicity against human Hep2 cells	[PMID: 24211022]
HEp-2	EC₅₀	0.01 μM Compound: 11f	Antiviral activity against Respiratory syncytial virus A2 infected in human Hep2 cells after 3 days by ELISA Antiviral activity against Respiratory syncytial virus A2 infected in human Hep2 cells after 3 days by ELISA	[PMID: 24211022]
HEp-2	EC₅₀	1 μM Compound: 11f	Antiviral activity against Respiratory syncytial virus B-Washington infected in human Hep2 cells after 3 days by ELISA Antiviral activity against Respiratory syncytial virus B-Washington infected in human Hep2 cells after 3 days by ELISA	[PMID: 24211022]

Chemical Information

CAS No. 1516772-44-3
Masse moléculaire 633.76
Formule C₃₆H₃₅N₅O₄S
SMILES

O=C(C(S1)=CC2=C1C3=CC=CC=C3N(C(C4=CC=C(NC(C5=CC=CN=C5N(CC6)CCC76COC7)=O)C=C4)=O)CC2)NC8CC8
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Molecular Biology

RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Noton SL, et al. Respiratory Syncytial Virus Inhibitor AZ-27 Differentially Inhibits Different Polymerase Activities at the Promoter. J Virol. 2015 Aug;89(15):7786-98. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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