AZ-27
AZ-27 is a respiratory syncytial virus (RSV) inhibitor. AZ-27 can differentially suppress various RSV polymerase activities at the promoter, thereby inhibiting the early stages of mRNA transcription and genome replication by targeting the promoter.
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- CAS No.: 1516772-44-3
- Formule: C36H35N5O4S
- Masse moléculaire:633.76
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BHK-21 | EC50 |
0.01 μM
Compound: 11f
|
Antiviral activity against Respiratory syncytial virus A2 infected in hamster BHK21 cells after 2 days by luciferase reporter gene assay
Antiviral activity against Respiratory syncytial virus A2 infected in hamster BHK21 cells after 2 days by luciferase reporter gene assay
|
[PMID: 24211022] |
| HEp-2 | CC50 |
>50 μM
Compound: 11f
|
Cytotoxicity against human Hep2 cells
Cytotoxicity against human Hep2 cells
|
[PMID: 24211022] |
| HEp-2 | EC50 |
0.01 μM
Compound: 11f
|
Antiviral activity against Respiratory syncytial virus A2 infected in human Hep2 cells after 3 days by ELISA
Antiviral activity against Respiratory syncytial virus A2 infected in human Hep2 cells after 3 days by ELISA
|
[PMID: 24211022] |
| HEp-2 | EC50 |
1 μM
Compound: 11f
|
Antiviral activity against Respiratory syncytial virus B-Washington infected in human Hep2 cells after 3 days by ELISA
Antiviral activity against Respiratory syncytial virus B-Washington infected in human Hep2 cells after 3 days by ELISA
|
[PMID: 24211022] |
Chemical Information
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CAS No. 1516772-44-3
-
Masse moléculaire 633.76
-
Formule C36H35N5O4S
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SMILES
O=C(C(S1)=CC2=C1C3=CC=CC=C3N(C(C4=CC=C(NC(C5=CC=CN=C5N(CC6)CCC76COC7)=O)C=C4)=O)CC2)NC8CC8
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Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)