BCN-PEG6-OH
BCN-PEG6-OH is a neutralizing agent and anticoagulant inhibitor containing strained alkyne. BCN-PEG6-OH undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) click reaction with azido-Warfarin to generate an inactive product that can be rapidly cleared via the kidneys. In mice, BCN-PEG6-OH effectively reduces the anticoagulant activity of azido-Warfarin in a dose-dependent manner, normalizes prothrombin time, and exhibits no inherent anticoagulant or procoagulant effects when administered alone. BCN-PEG6-OH can be used for the research of drug-induced coagulopathy.
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- CAS No.: 2270844-08-9
- Formule: C23H39NO8
- Masse moléculaire:457.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL6N Mice (male, 8-12 weeks of age, drug-induced coagulopathy model via azido-Warfarin administration)[1]
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Dosage:26 mg/kg; 52 mg/kg
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Administration:s.c.; 2 doses with 24-hour interval, 5 minutes after each i.p. injection of azido-Warfarin
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Result:Reduced the PT fold change (relative to vehicle) from 3.61 (azido-Warfarin alone) to 2.39.
Reduced the PT fold change from 3.61 to 1.75, a level that was not significantly different from vehicle controls.
Led to in vivo formation of the inactive clicked product 10, with plasma concentrations of free azido-Warfarin dropping below the limit of detection within 60 minutes, and 95.3% of the clicked product recovered in urine indicating rapid renal clearance.
Chemical Information
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CAS No. 2270844-08-9
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Masse moléculaire 457.56
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Formule C23H39NO8
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SMILES
C(OC(NCCOCCOCCOCCOCCOCCO)=O)[C@H]1[C@@]2([C@]1(CCC#CCC2)[H])[H]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BCN-PEG6-OH Related Classifications
HY-183649 Related Classifications
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