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Belcesiran

(Synonyms: DCR-S1459)

Belcesiran, a siRNA, is an alpha 1 antitrypsin (A1AT) inhibitor that acts by allowing the liver to synthesise the A1AT protein and pass it into the bloodstream.

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  • CAS No.: 2375562-54-0
  • Formule: C666H877O417N231F15P57S6
  • Masse moléculaire:21033.20
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Belcesiran Chemical Structure
    Belcesiran Chemical Structure
CAS No.: 2375562-54-0
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  • Belcesiran Chemical Structure
    Belcesiran Chemical Structure RNA, (Am-sp-Am-(2'-deoxy-2'-fluoro)A-Cm-Cm-Cm-Um-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-Um-Cm-Um-(2'-deoxy-2'-fluoro)U-Am-Am-Am-Gm-Cm-Am-Gm-Cm-Cm-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]G-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-Gm-Gm-Cm-Um-Gm-Cm), complex with RNA ([1-de-β-D-ribofuranosyl-1-[(2R,3R,4S,5S)-tetrahydro-4-hydroxy-5-[(hydroxymethoxyphosphinyl)methoxy]-3-methoxy-2-furanyl]]U-(4'→5')-sp-(2'-deoxy-2'-fluoro)U-sp-(2'-deoxy-2'-fluoro)U-sp-Am-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)A-Am-Gm-Am-Cm-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)G-Gm-Um-(2'-deoxy-2'-fluoro)U-Um-sp-Gm-sp-Gm) (1:1)
    1/16
  • RNA, (Am-sp-Am-(2'-deoxy-2'-fluoro)A-Cm-Cm-Cm-Um-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-Um-Cm-Um-(2'-deoxy-2'-fluoro)U-Am-Am-Am-Gm-Cm-Am-Gm-Cm-Cm-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]G-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-Gm-Gm-Cm-Um-Gm-Cm), complex with RNA ([1-de-β-D-ribofuranosyl-1-[(2R,3R,4S,5S)-tetrahydro-4-hydroxy-5-[(hydroxymethoxyphosphinyl)methoxy]-3-methoxy-2-furanyl]]U-(4'→5')-sp-(2'-deoxy-2'-fluoro)U-sp-(2'-deoxy-2'-fluoro)U-sp-Am-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)A-Am-Gm-Am-Cm-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)G-Gm-Um-(2'-deoxy-2'-fluoro)U-Um-sp-Gm-sp-Gm) (1:1)