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Cat. No.: HY-123560

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BKM-570

BKM-570 is a nonpeptide bradykinin antagonist with anticancer effects. BKM-570 can be used in the study of lung cancer, prostate cancer and ovarian cancer.

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CAS No.: 259885-54-6
Formule: C₃₄H₃₄Cl₂F₅N₃O₃
Masse moléculaire:698.55

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BKM-570 Chemical Structure

CAS No.: 259885-54-6

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
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Activité biologique

Description

BKM-570 is a nonpeptide bradykinin antagonist with anticancer effects. BKM-570 can be used in the study of lung cancer, prostate cancer and ovarian cancer^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
C6	IC₅₀	4 μM Compound: BKM-570	Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
Cancer cell lines	IC₅₀	1.8 μM Compound: BKM-570	Cytotoxicity against human Small cell lung cancer cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human Small cell lung cancer cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
Granta	IC₅₀	63.3 μM Compound: BKM-570	Cytotoxicity against human Granta cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human Granta cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
HEK293	IC₅₀	3.8 μM Compound: BKM-570	Cytotoxicity against HEK293 cells overexpressing CHI3L1 gene assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against HEK293 cells overexpressing CHI3L1 gene assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
JeKo-1	IC₅₀	49.3 μM Compound: BKM-570	Cytotoxicity against human Jeko cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human Jeko cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
U-373MG ATCC	IC₅₀	3.3 μM Compound: BKM-570	Cytotoxicity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]

Chemical Information

CAS No. 259885-54-6
Masse moléculaire 698.55
Formule C₃₄H₃₄Cl₂F₅N₃O₃
SMILES

O=C([C@@H](NC(/C=C/C1=C(C(F)=C(C(F)=C1F)F)F)=O)CC2=CC=C(C=C2)OCC3=C(C=CC=C3Cl)Cl)NC4CC(C)(C)NC(C)(C)C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Stephanie Jutras, et al. Strong cytotoxic effect of the bradykinin antagonist BKM-570 in ovarian cancer cells--analysis of the molecular mechanisms of its antiproliferative action. FEBS J. 2010 Dec;277(24):5146-60. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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BKM-570

Voir tous les produits spécifiques à Isoform Bradykinin Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

BKM-570 Related Classifications

HY-123560 Related Classifications