CHF 4227 free base
CHF 4227 free base is an orally active and selective estrogen receptor modulator (SERM) with high affinity to the human estrogen receptor-α and -β (Ki values of 0.017 nM and 0.099 nM, respectively).
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- CAS No.: 444643-64-5
- Formule: C30H33NO4
- Masse moléculaire:471.59
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
hERα 0.017 nM (Ki) |
hERβ 0.099 nM (Ki) |
In Vivo
In ovariectomized (OVX) rats treated orally for 4 weeks, CHF 4227 free basecompletely inhibits OVX effects on bone density (ED50[1].
CHF 4227 free base reduces serum cholesterol (ED50[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 444643-64-5
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Masse moléculaire 471.59
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Formule C30H33NO4
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SMILES
OC1=CC=C2C(CC3=CC=C(OCCN4CCCCC4)C=C3)=C(C5=CC=C(OC)C=C5)COC2=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Elisabetta Galbiati, et al. Pharmacological actions of a novel, potent, tissue-selective benzopyran estrogen. J Pharmacol Exp Ther. 2002 Oct;303(1):196-203. [Content Brief]
[2]. Maurizio Civelli, et al. Single and multiple ascending dose studies of a novel tissue-selective oestrogen receptor modulator, CHF 4227, in healthy postmenopausal women. Br J Clin Pharmacol. 2007 Sep;64(3):304-16. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CHF 4227 free base Related Classifications
HY-107045 Related Classifications
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