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Cat. No.: HY-188169

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Disuprazole

Name: Disuprazole
Brand: MedChemExpress
SKU: HY-188169
Availability: PreOrder

(Synonyms: U-69167)

Disuprazole (U-69167) is an orally active benzimidazole proton pump inhibitor that inhibits gastric H⁺/K⁺-ATPase with an IC₅₀ of 2 × 10^-5 M. Disuprazole reduces gastric acid secretion by inhibiting gastric proton pump activity. Disuprazole can be used in research related to gastric acid secretion and peptic ulcer.

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CAS No.: 99499-40-8
Formule: C₁₆H₁₇N₃OS₂
Masse moléculaire:331.46

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Please store the product under the recommended conditions in the Certificate of Analysis.

Disuprazole Chemical Structure

CAS No.: 99499-40-8

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

IC₅₀ & Target

^[1]

Hog gastric H+/K+-ATPase

20 μM (IC₅₀)

In Vitro

Disuprazole (10 ns) binds to CYP2C9 in an extended conformation 10~15 Å above the heme, and its binding site is stabilized by a water-mediated hydrogen-bonding network and strong hydrophobic interactions^[2].
Disuprazole inhibits hog gastric (H⁺-K⁺)-ATPase activity with an IC₅₀ of 2 × 10⁻⁵ M^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Disuprazole (U-69167) (compound 26) (s.c. or p.o.; single administration; 3 h) inhibits gastric H⁺/K⁺-ATPase activity in male Sprague-Dawley rats with ED₅₀ values of 1.0 mg/kg and 15 mg/kg, respectively^[1].
Disuprazole (s.c. or oral administration; single dose) inhibits gastric acid secretion in Carbachol (HY-B1208)-stimulated pylorus-ligated Shay rats, with ED₅₀ values of < 1.0 mg/kg and 2.0-5.0 mg/kg, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 99499-40-8
Masse moléculaire 331.46
Formule C₁₆H₁₇N₃OS₂
SMILES

O=S(CC1=NC=CC(SCC)=C1C)C2=NC3=C(N2)C=CC=C3
Synonyms

U-69167
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Sih JC, et al. Studies on (H(+)-K+)-ATPase inhibitors of gastric acid secretion. Prodrugs of 2-[(2-pyridinylmethyl)sulfinyl]benzimidazole proton-pump inhibitors. Journal of medicinal chemistry. 1991 Mar;34(3):1049-62.

[2]. Shi R, et al. Exploration of the binding of proton pump inhibitors to human P450 2C9 based on docking and molecular dynamics simulation. J Mol Model. 2011;17(8):1941-1951.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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Disuprazole