99499-40-8
99499-40-8
Chemical Structure
Disuprazole
Synonym(s): U-69167
- CAS No.: 99499-40-8
- Formula:C16H17N3OS2
- Molecular Weight:331.46
IUPAC Name: 2-(((4-(ethylthio)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
InChIKey: YWQUFKJVMWHDSN-UHFFFAOYSA-N
SMILES: O=S(CC1=NC=CC(SCC)=C1C)C2=NC3=C(N2)C=CC=C3
Biological Activity: Disuprazole (U-69167) is an orally active benzimidazole proton pump inhibitor that inhibits gastric H+/K+-ATPase with an IC50 of 2 × 10-5 M. Disuprazole reduces gastric acid secretion by inhibiting gastric proton pump activity. Disuprazole can be used in research related to gastric acid secretion and peptic ulcer[1][2].
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Disuprazole | Disuprazole (U-69167) is an orally active benzimidazole proton pump inhibitor that inhibits gastric H+/K+-ATPase with an IC50 of 2 × 10-5 M. Disuprazole reduces gastric acid secretion by inhibiting gastric proton pump activity. Disuprazole can be used in research related to gastric acid secretion and peptic ulcer. | |||||||||||||||||||||
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References
- [1]. Sih JC, et al. Studies on (H(+)-K+)-ATPase inhibitors of gastric acid secretion. Prodrugs of 2-[(2-pyridinylmethyl)sulfinyl]benzimidazole proton-pump inhibitors. Journal of medicinal chemistry. 1991 Mar;34(3):1049-62.
- [2]. Shi R, et al. Exploration of the binding of proton pump inhibitors to human P450 2C9 based on docking and molecular dynamics simulation. J Mol Model. 2011;17(8):1941-1951.
