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Cat. No.: HY-182320

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DRL-17822

Name: DRL-17822
Brand: MedChemExpress
SKU: HY-182320
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DRL-17822 is a selective cholesteryl ester transfer protein (CETP) inhibitor. DRL-17822 increases high-density lipoprotein levels. The exposure of DRL-17822 nanocrystal formulation increases significantly after a high-fat breakfast. The exposure of DRL-17822 in the fasted state is higher than that of its nanocrystal formulation. DRL-17822 can be used in the research of type II hyperlipidemia and atherosclerotic cardiovascular disease.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 898911-09-6
Formule: C₃₀H₃₁F₆N₇
Masse moléculaire:603.60

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DRL-17822 Chemical Structure

CAS No.: 898911-09-6

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
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Activité biologique

Description

In Vitro

DRL-17822 does not cross Caco-2 cell monolayers in measurable amounts, and may moderately inhibit recombinant human CYP3A4^[1].
DRL-17822 is highly lipophilic, water-insoluble, and extensively bound to plasma proteins across species^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DRL-17822 (10 mg/kg; i.v.; single dose) is hardly excreted in urine but shows moderate fecal excretion in male Wistar rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (male)^[1]
Dosage:

10 mg/kg
Administration:

i.v.; single dose
Result:

Recovered approximately 0.004% of the dose in urine within 24 hours.
Recovered approximately 12.5% of the dose in feces within 24 hours.

Related Protocols :

Research Protocol for Cardiovascular Diseases

Chemical Information

CAS No. 898911-09-6
Masse moléculaire 603.60
Formule C₃₀H₃₁F₆N₇
SMILES

FC(F)(C1=CC(CN(CC2=CC3=C(N=C2N(CC4CC4)CC5CC5)C(C)=CC=C3)C6=NN(C)N=N6)=CC(C(F)(F)F)=C1)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Kruithof AC, et al. Effect of Food on the Pharmacokinetics of 2 Formulations of DRL-17822, a Novel Selective Cholesteryl Ester Transfer Protein (CETP) Inhibitor, in Healthy Males. Clin Pharmacol Drug Dev. 2019;8(8):1042-1052. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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