Mx1 - MX dynamin-like GTPase 1 Gene

Also Known as Mx; Mx-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17857

Summary

This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral Infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to the Influenza Virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a deletion or a nonsense mutation that results in a non-functional gene product. [provided by RefSeq, Aug 2015]

Mx1 Products (1)

mRNA Protein Name
NM_010846.1 NP_034976.1 protein Mx1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
11716541 MGI
Cellular Component GO Annotation Evidence Références Source
located in nucleus IDA
IDA: Inferred from direct assay
11716541 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Mx1

  • interferon-induced GTP-binding protein Mx1

  • myxoma resistance protein 1

  • myxovirus (influenza virus) resistance 1

  • myxovirus (influenza) resistance 1 polypeptide

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit Effect
Pureté Phase
HY-106031 F-14512 Inhibitor 98.04% Phase 2
HY-12098 Verubulin hydrochloride Inhibitor 98.71% Phase 2
HY-106401 Penclomedine / Phase 1

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-160229 ssRNA40 sodium 98.34% Unkown
HY-N0167 Gynostemma Extract Inhibitor 99.92% Unkown
HY-123805 KIN1400 98.1% Unkown
HY-10615 A-620223 Inhibitor 98.84% Unkown
HY-162465 BDW568 Agonist 99.4% Unkown
HY-RS18454 Mx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-106031A F-14512 hydrochloride Inhibitor / Unkown
HY-131438 GI-149893 Inhibitor / Unkown
HY-14687 (rac)-Talazoparib Inhibitor / Unkown
HY-181796 TLR7 antagonist-1 / Unkown
HY-RS08859 MX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121372 Lactandrate / Unkown
HY-RS24935 Mx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mx1 NCBI NCBI:4599