Bcar1 - BCAR1 scaffold protein, Cas family member Gene

Also Known as Cas; Crkas; P130CAS

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25414

Summary

Enables protein domain specific binding activity. Involved in several processes, including cellular response to endothelin; cellular response to nitric oxide; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in focal adhesion and plasma membrane. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to human BCAR1 (BCAR1 scaffold protein, Cas family member). [provided by Alliance of Genome Resources, Apr 2022]

Bcar1 Products (3)

mRNA Protein Name
NM_001395122.1 NP_001382051.1 breast cancer anti-estrogen resistance protein 1 isoform 1
NM_001395123.1 NP_001382052.1 breast cancer anti-estrogen resistance protein 1 isoform 2
NM_012931.2 NP_037063.2 breast cancer anti-estrogen resistance protein 1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
8940134 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
12011056 RGD
Biological Process GO Annotation Evidence Références Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
12011056 RGD
involved in cell migration IMP
IMP: Inferred from mutant phenotype
12011056 RGD
involved in cellular response to endothelin IPI
IPI: Inferred from physical interaction
12719447 RGD
involved in cellular response to nitric oxide IPI
IPI: Inferred from physical interaction
12714323 RGD
involved in epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
9325334 RGD
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
9627109 RGD
involved in negative regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
15817476 RGD
involved in neurotrophin TRK receptor signaling pathway IDA
IDA: Inferred from direct assay
8631760 RGD
Cellular Component GO Annotation Evidence Références Source
located in focal adhesion IDA
IDA: Inferred from direct assay
8662921 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

breast cancer anti-estrogen resistance protein 1

  • BCAR1, Cas family scaffold protein

  • BCAR1, Cas family scaffolding protein

  • CRK-associated substrate

  • breast cancer anti-estrogen resistance 1

  • v-crk-associated tyrosine kinase substrate

Bcar1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Cross
Bcar1 Q63767 PTPN1 Homo sapiens P18031
Pull Down
8940134
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS01397 BCAR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcar1 NCBI NCBI:9564