RAB7B - RAB7B, member RAS oncogene family Gene
Also Known as RAB7
Species: Homo sapiens
About RAB7B
This gene has 5 transcripts (splice variants), 122 orthologues and 68 paralogues. Broad expression in skin (RPKM 15.7), gall bladder (RPKM 6.5) and 20 other tissues.
Summary
Predicted to enable GTP binding activity and GTPase activity. Involved in late endosome to Golgi transport; positive regulation of megakaryocyte differentiation; and regulation of gene expression. Located in cytoplasmic vesicle; lysosome; and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
RAB7B Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001164522.3 | NP_001157994.1 | ras-related protein Rab-7b isoform a |
| NM_001304839.2 | NP_001291768.1 | ras-related protein Rab-7b isoform b |
| NM_177403.6 | NP_796377.3 | ras-related protein Rab-7b isoform a |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| Biological Process GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| involved in late endosome to Golgi transport |
IMP
IMP: Inferred from mutant phenotype
|
20375062 | GOA |
| involved in positive regulation of NF-kappaB transcription factor activity |
IMP
IMP: Inferred from mutant phenotype
|
20953574 | GOA |
| involved in positive regulation of interleukin-6 production |
IMP
IMP: Inferred from mutant phenotype
|
20953574 | GOA |
| involved in positive regulation of megakaryocyte differentiation |
IMP
IMP: Inferred from mutant phenotype
|
20953574 | GOA |
| Cellular Component GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| located in Golgi apparatus |
IDA
IDA: Inferred from direct assay
|
20375062 | GOA |
| located in late endosome |
IDA
IDA: Inferred from direct assay
|
20375062 | GOA |
| located in lysosome |
IDA
IDA: Inferred from direct assay
|
20375062 | GOA |
| located in phagocytic vesicle |
IDA
IDA: Inferred from direct assay
|
21255211 | GOA |
| located in trans-Golgi network |
IDA
IDA: Inferred from direct assay
|
20375062 | GOA |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
ras-related protein Rab-7b |
|
RAB7B Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
RAB7B | Q96AH8 | APPBP2 | Homo sapiens | Q92624 | 32296183 | |
|
Intra
|
RAB7B | Q96AH8 | APPBP2 | Homo sapiens | Q92624 | 32296183 |
RAB7B Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P82053 | Rab7B Antibody (YA1798) | WB | Human |
| HY-P82053A | Rab7B Antibody (YA1798)(PBS only) | WB | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Charcot-Marie-Tooth Disease, Axonal, Type 2b |
|
|
| Pontocerebellar Hypoplasia, Type 2e |
|
|
| Neuropathy, Hereditary Sensory And Autonomic, Type I, With Cough And Gastroesophageal Reflux |
|
|
| Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7 |
|
|
| Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive |
|
|
| Charcot-Marie-Tooth Disease And Deafness |
|
|
| Charcot-Marie-Tooth Disease, Axonal, Type 2e |
|
|
| Vici Syndrome |
|
|
| Charcot-Marie-Tooth Disease, Axonal, Type 2l |
|
|
| Charcot-Marie-Tooth Disease, Type 4j |
|
|
| Charcot-Marie-Tooth Disease, Dominant Intermediate B |
|
|
| Legionnaire Disease |
|
|
| Spinocerebellar Ataxia, Autosomal Recessive 15 |
|
|
| Neuropathy, Hereditary Sensory, Type Id |
|
|
| Charcot-Marie-Tooth Disease, Type 4b2 |
|
|
| Legionellosis |
|
|
| Cataract 44 |
|
|
| C Syndrome |
|
|
| Niemann-Pick Disease, Type C1 |
|
|
| Warburg Micro Syndrome 1 |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Niemann-Pick Disease |
|
|
| Hereditary Sensory And Autonomic Neuropathy Type 1 |
|
|
| Neuronal Ceroid Lipofuscinosis |
|
|
| Neuromuscular Disease |
|
|
| Hermansky-Pudlak Syndrome |
|
|
| Hereditary Spastic Paraplegia |
|
|
| Charcot-Marie-Tooth Disease |
|
|
| Peripheral Nervous System Disease |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | RAB7B | VGNC | VGNC:97594 |
| Macaca mulatta | RAB7B | VGNC | VGNC:106480 |
| Rattus norvegicus | RAB7B | RGD | RGD:1562617 |
| Bos taurus | RAB7B | VGNC | VGNC:33661 |
| Canis familiaris | RAB7B | VGNC | VGNC:45294 |
| Mus musculus | RAB7B | MGD | MGI:2442295 |
| Others | RAB7B | NCBI |